Three topological features of regulatory networks control life-essential and specialized subsystems.
Autor: | Wolf IR; Department of Bioprocess and Biotechnology, School of Agriculture, São Paulo State University (UNESP), Botucatu, São Paulo, 18610-034, Brazil., Simões RP; Department of Bioprocess and Biotechnology, School of Agriculture, São Paulo State University (UNESP), Botucatu, São Paulo, 18610-034, Brazil.; Medical School, Sao Paulo State University (UNESP), Botucatu, São Paulo, 18618-687, Brazil., Valente GT; Department of Bioprocess and Biotechnology, School of Agriculture, São Paulo State University (UNESP), Botucatu, São Paulo, 18610-034, Brazil. valentegt@gmail.com.; Max-Planck-Institut für Herz- und Lungenforschung, Max Planck Institute, 61231, Bad Nauheim, Hessen, Germany. valentegt@gmail.com. |
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Jazyk: | angličtina |
Zdroj: | Scientific reports [Sci Rep] 2021 Dec 20; Vol. 11 (1), pp. 24209. Date of Electronic Publication: 2021 Dec 20. |
DOI: | 10.1038/s41598-021-03625-w |
Abstrakt: | Gene regulatory networks (GRNs) play key roles in development, phenotype plasticity, and evolution. Although graph theory has been used to explore GRNs, associations amongst topological features, transcription factors (TFs), and systems essentiality are poorly understood. Here we sought the relationship amongst the main GRN topological features that influence the control of essential and specific subsystems. We found that the K (© 2021. The Author(s).) |
Databáze: | MEDLINE |
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