Association between cardiovascular risk factors and intracranial hemorrhage in patients with acute leukemia.

Autor: Cornelissen LL; Jon J van Rood Center for Clinical Transfusion Research, LUMC/Sanquin, Leiden, The Netherlands.; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands., Kreuger AL; Jon J van Rood Center for Clinical Transfusion Research, LUMC/Sanquin, Leiden, The Netherlands.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Caram-Deelder C; Jon J van Rood Center for Clinical Transfusion Research, LUMC/Sanquin, Leiden, The Netherlands.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Huisman MV; Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands., Middelburg RA; Jon J van Rood Center for Clinical Transfusion Research, LUMC/Sanquin, Leiden, The Netherlands.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Kerkhoffs JLH; Jon J van Rood Center for Clinical Transfusion Research, LUMC/Sanquin, Leiden, The Netherlands.; Department of Hematology, Haga Teaching Hospital, Den Haag, The Netherlands., von dem Borne PA; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands., Beckers EAM; Department of Hematology, Maastricht University Medical Center, Maastricht, The Netherlands., de Vooght KMK; Central Diagnostic Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands., Kuball J; Department of Hematology, University Medical Center Utrecht, Utrecht, The Netherlands., van der Bom JG; Jon J van Rood Center for Clinical Transfusion Research, LUMC/Sanquin, Leiden, The Netherlands.; Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands., Zwaginga JJ; Jon J van Rood Center for Clinical Transfusion Research, LUMC/Sanquin, Leiden, The Netherlands.; Department of Hematology, Leiden University Medical Center, Leiden, The Netherlands.
Jazyk: angličtina
Zdroj: European journal of haematology [Eur J Haematol] 2022 Apr; Vol. 108 (4), pp. 310-318. Date of Electronic Publication: 2022 Jan 18.
DOI: 10.1111/ejh.13737
Abstrakt: Background: Intracranial hemorrhage is seen more frequently in acute leukemia patients compared to the general population. Besides leukemia-related risk factors, also risk factors that are present in the general population might contribute to hemorrhagic complications in leukemia patients. Of those, cardiovascular risk factors leading to chronic vascular damage could modulate the occurrence of intracranial hemorrhage in these patients, as during their disease and treatment acute endothelial damage occurs due to factors like thrombocytopenia and inflammation.
Objectives: Our aim was to explore if cardiovascular risk factors can predict intracranial hemorrhage in acute leukemia patients.
Methods: In a case-control study nested in a cohort of acute leukemia patients, including 17 cases with intracranial hemorrhage and 55 matched control patients without intracranial hemorrhage, data on cardiovascular risk factors were collected for all patients. Analyses were performed via conditional logistic regression.
Results: Pre-existing hypertension and ischemic heart disease in the medical history were associated with intracranial hemorrhage, with an incidence rate ratio of 12.9 (95% confidence interval [CI] 1.5 to 109.2) and 12.1 (95% CI 1.3 to110.7), respectively.
Conclusion: Both pre-existing hypertension and ischemic heart disease seem to be strong predictors of an increased risk for intracranial hemorrhage in leukemia patients.
(© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje