Depth of Invasion as an Independent Predictor of Survival in Patients of Stage III Squamous Cell Carcinoma of the Oral Tongue.

Autor: Tandon S; Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Ahlawat P; Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Pasricha S; Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Purohit S; Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Simson DK; Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Dobriyal K; Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Umesh P; Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Mishra M; Division of Medical Physicis, Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Kumar L; Division of Medical Physicis, Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Karimi AM; Department of Oncology, University Hospital of Derby and Burton, Derby, England, United Kingdom., M J; Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India., Gairola M; Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.
Jazyk: angličtina
Zdroj: The Laryngoscope [Laryngoscope] 2022 Aug; Vol. 132 (8), pp. 1594-1599. Date of Electronic Publication: 2021 Dec 16.
DOI: 10.1002/lary.29990
Abstrakt: Objective: Depth of invasion (DOI) has been incorporated in the new AJCC 8th classification. However, even with this new AJCC classification stage III oral tongue squamous cell carcinoma (OTSCC) remains a heterogenous group. The study aims at finding a discreet group within stage III using DOI as a cut-off of 10 mm.
Methods: The institutional database was reviewed from 2012 to 2018 for postoperative stage III OTSCC patients who subsequently received postoperative radiotherapy. Ninety-six patients matched the inclusion criteria. Two groups were created using a DOI cut-off of 10 mm (superficial and deep groups). The groups were analyzed for overall survival (OS) and relapse-free survival (RFS).
Results: The baseline and treatment characteristics were comparable between the groups except for the higher number of extensive surgeries, endophytic configuration, pT3 and, DOI in the deep group. For a median follow-up of 40.5 (range: 4-139) months, the median OS and RFS for the superficial group were not reached. The median OS and RFS for the deep group were 101 (range: 73.7-128.3) and 60 (range: 46.6-73.4) months, respectively. The difference was statistically significant for median RFS (P = .008) and trended toward significance for median OS (P = .066) for the superficial group. Multivariate Cox regression analysis showed DOI cut-off as a significant predictor for RFS but not for OS.
Conclusion: DOI significantly predicts poor RFS. However, showed a trend toward poor OS. This study hints toward a possibility of sub-dividing stage III OTSCC based on DOI cut-off.
Level of Evidence: 3 (Retrospective cohort study) Laryngoscope, 132:1594-1599, 2022.
(© 2021 The American Laryngological, Rhinological and Otological Society, Inc.)
Databáze: MEDLINE
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