Familial clustering of psychiatric disorders and low IQ.

Autor:	Weiser M; Department of Psychiatry, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel.; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel., Frenkel O; Department of Psychiatry, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel., Fenchel D; Department of Psychiatry, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel., Tzur D; Medical Corps, Israel Defense Force, Israel., Sandin S; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Janecka M; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Levi L; Department of Psychiatry, Chaim Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel., Davidson M; University of Nicosia Medical School, Nicosia, Cyprus., Laor L; Medical Corps, Israel Defense Force, Israel., Fruchter E; Medical Corps, Israel Defense Force, Israel.; Department of Psychiatry, Rambam Medical Center, Haifa, Israel.; Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Reichenberg A; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Jazyk:	angličtina
Zdroj:	Psychological medicine [Psychol Med] 2023 May; Vol. 53 (7), pp. 2878-2884. Date of Electronic Publication: 2021 Dec 16.
DOI:	10.1017/S0033291721004852
Abstrakt:	Background: Although the ICD and DSM differentiate between different psychiatric disorders, these often share symptoms, risk factors, and treatments. This was a population-based, case-control, sibling study examining familial clustering of all psychiatric disorders and low IQ, using data from the Israel Draft-Board Registry on all Jewish adolescents assessed between 1998 and 2014. Methods: We identified all cases with autism spectrum disorder (ASD, N = 2128), severe intellectual disability (ID, N = 9572), attention-deficit hyperactive disorder (ADHD) ( N = 3272), psychotic ( N = 7902), mood ( N = 9704), anxiety ( N = 10 606), personality ( N = 24 816), or substance/alcohol abuse ( N = 791) disorders, and low IQ (⩾2 SDs below the population mean, N = 31 186). Non-CNS control disorders were adolescents with Type-1 diabetes ( N = 2427), hernia ( N = 29 558) or hematological malignancies ( N = 931). Each case was matched with 10 age-matched controls selected at random from the Draft-Board Registry, with replacement, and for each case and matched controls, we ascertained all full siblings. The main outcome measure was the relative recurrence risk (RRR) of the sibling of a case having the same (within-disorder RRR) or a different (across-disorder RRR) disorder. Results: Within-disorder RRRs were increased for all diagnostic categories, ranging from 11.53 [95% confidence interval (CI): 9.23-14.40] for ASD to 2.93 (95% CI: 2.80-3.07) for personality disorders. The median across-disorder RRR between any pair of psychiatric disorders was 2.16 (95% CI: 1.45-2.43); the median RRR between low IQ and any psychiatric disorder was 1.37 (95% CI: 0.93-1.98). There was no consistent increase in across-disorder RRRs between the non-CNS disorders and psychiatric disorders and/or low IQ. Conclusion: These large population-based study findings suggest shared etiologies among most psychiatric disorders, and low IQ.
Databáze:	MEDLINE
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