The impact of worst pattern of invasion on the extension of surgical margins in oral squamous cell carcinoma.

Autor: Köhler HF; Department of Head and Neck Surgery and Otolaryngology, A C Camargo Cancer Center, São Paulo, Brazil., Vartanian JG; Department of Head and Neck Surgery and Otolaryngology, A C Camargo Cancer Center, São Paulo, Brazil., Pinto CAL; Department of Pathology, A C Camargo Cancer Center, São Paulo, Brazil., da Silva Rodrigues IFP; Department of Pathology, A C Camargo Cancer Center, São Paulo, Brazil., Kowalski LP; Department of Head and Neck Surgery and Otolaryngology, A C Camargo Cancer Center, São Paulo, Brazil.; Department of Surgery, São Paulo University Medical School, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Head & neck [Head Neck] 2022 Mar; Vol. 44 (3), pp. 691-697. Date of Electronic Publication: 2021 Dec 14.
DOI: 10.1002/hed.26956
Abstrakt: Background: To evaluate margins for oral carcinoma according to types of invasion front.
Methods: Retrospective cohort of 772 patients with worst pattern of invasion (WPOI) graded 1-5. Local recurrence was the outcome of interest.
Results: Local recurrences occurred in 164 patients (21.2%) and was affected by WPOI type 4/5, margin distance, perineural invasion, and adjuvant radiotherapy. In patients with WPOI types 1/2/3, a cutoff of 1.7 mm was considered ideal margin extent and in patients with WPOI types 4/5, the cutoff was 7.8 mm. Patients below these thresholds had a significantly higher incidence of local recurrence.
Conclusions: Different WPOI determine the ideal extent of surgical margins as 1.7 mm for patients with types 1-3, and 7.8 mm in patients with types 4/5.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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