Myeloperoxidase: Growing importance in cancer pathogenesis and potential drug target.

Autor: Valadez-Cosmes P; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria., Raftopoulou S; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria., Mihalic ZN; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria., Marsche G; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria., Kargl J; Otto Loewi Research Center, Division of Pharmacology, Medical University of Graz, Graz, Austria. Electronic address: julia.kargl@medunigraz.at.
Jazyk: angličtina
Zdroj: Pharmacology & therapeutics [Pharmacol Ther] 2022 Aug; Vol. 236, pp. 108052. Date of Electronic Publication: 2021 Dec 08.
DOI: 10.1016/j.pharmthera.2021.108052
Abstrakt: Myeloperoxidase is a heme-peroxidase which makes up approximately 5% of the total dry cell weight of neutrophils where it is predominantly found in the primary (azurophilic) granules. Other cell types, such as monocytes and certain macrophage subpopulations also contain myeloperoxidase, but to a much lesser extent. Initially, the function of myeloperoxidase had been mainly associated with its ability as a catalyzer of reactive oxidants that help to clear pathogens. However, over the past years non-canonical functions of myeloperoxidase have been described both in health and disease. Attention has been specially focused on inflammatory diseases, in which an exacerbate infiltration of leukocytes can favor a poorly-controlled production and release of myeloperoxidase and its oxidants. There is compelling evidence that myeloperoxidase derived oxidants contribute to tissue damage and the development and propagation of acute and chronic vascular inflammation. Recently, neutrophils have attracted much attention within the large diversity of innate immune cells that are part of the tumor microenvironment. In particular, neutrophil-derived myeloperoxidase may play an important role in cancer development and progression. This review article aims to provide a comprehensive overview of the roles of myeloperoxidase in the development and progression of cancer. We propose future research approaches and explore prospects of inhibiting myeloperoxidase as a strategy to fight against cancer.
Competing Interests: Declaration of Competing Interest All authors declare that there are no conflicts of interest
(Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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