Pathogenesis and Treatment of Cytokine Storm Induced by Infectious Diseases.

Autor: Tang XD; College of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang 712100, China., Ji TT; College of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang 712100, China., Dong JR; College of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang 712100, China., Feng H; College of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang 712100, China., Chen FQ; College of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang 712100, China., Chen X; College of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang 712100, China., Zhao HY; College of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang 712100, China., Chen DK; College of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang 712100, China., Ma WT; College of Veterinary Medicine, Northwest A&F University, Yangling District, Xianyang 712100, China.
Jazyk: angličtina
Zdroj: International journal of molecular sciences [Int J Mol Sci] 2021 Nov 30; Vol. 22 (23). Date of Electronic Publication: 2021 Nov 30.
DOI: 10.3390/ijms222313009
Abstrakt: Cytokine storm is a phenomenon characterized by strong elevated circulating cytokines that most often occur after an overreactive immune system is activated by an acute systemic infection. A variety of cells participate in cytokine storm induction and progression, with profiles of cytokines released during cytokine storm varying from disease to disease. This review focuses on pathophysiological mechanisms underlying cytokine storm induction and progression induced by pathogenic invasive infectious diseases. Strategies for targeted treatment of various types of infection-induced cytokine storms are described from both host and pathogen perspectives. In summary, current studies indicate that cytokine storm-targeted therapies can effectively alleviate tissue damage while promoting the clearance of invading pathogens. Based on this premise, "multi-omics" immune system profiling should facilitate the development of more effective therapeutic strategies to alleviate cytokine storms caused by various diseases.
Databáze: MEDLINE
Externí odkaz: