Relationship between CD4 + count, serum inflammatory cytokines, and oral melanotic hyperpigmentation in newly diagnosed HIV-seropositive patients: a nested case-control study.

Autor: Abe EO; Department of Oral Pathology/Oral Medicine, University College Hospital, Ibadan, Nigeria. Electronic address: eoabe83@yahoo.co.uk., Adisa AO; Department of Oral Pathology/Oral Medicine, University College Hospital, Ibadan, Nigeria., Adeyemi BF; Department of Oral Pathology/Oral Medicine, University College Hospital, Ibadan, Nigeria., Awolude OA; Department of Obstetrics and Gynaecology, University College Hospital, Ibadan, Nigeria., Owotade FJ; Department of Oral Pathology/Oral Medicine, Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife, Osun State, Nigeria.
Jazyk: angličtina
Zdroj: Oral surgery, oral medicine, oral pathology and oral radiology [Oral Surg Oral Med Oral Pathol Oral Radiol] 2022 Feb; Vol. 133 (2), pp. 182-188. Date of Electronic Publication: 2021 Oct 22.
DOI: 10.1016/j.oooo.2021.10.009
Abstrakt: Objective: Oral melanotic hyperpigmentation (OMH) in patients with human immunodeficiency virus (HIV) infection has been attributed to the use of antifungal or antiretroviral drugs, as well as HIV-induced cytokine dysregulation. This research aimed to determine the relationship between immunosuppression and cytokine dysregulation in newly diagnosed HIV-seropositive subjects with OMH.
Study Design: The study was conducted among newly diagnosed HIV-seropositive patients at the Infectious Disease Clinic, Ibadan, Nigeria. The cases were patients with OMH matched for age and sex with control subjects without OMH. CD4 + count and cytokine levels (interleukin-6 and tumor necrosis factor-α) were compared between the cases and control subjects. SPSS version 21 software was used for data analysis.
Results: Seventy newly diagnosed HIV-seropositive patients were studied, which comprised of 35 cases and 35 control subjects. The median CD4 + counts for cases and control subjects were 174 cells/mm 3 (interquartile range [IQR], 57-250) and 324 cells/mm 3 (IQR, 107-424), respectively. Severe immunosuppression (CD4 + count, ≤200 cells/mm 3 ) was found in over half of the study participants, being more prevalent among the cases than among the control group (P = .019). Serum cytokine levels did not significantly vary between the cases and control subjects.
Conclusions: There was a significant association between HIV-OMH and severe immunosuppression in the newly diagnosed HIV-seropositive patients.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: