Genetic polymorphisms of reproductive hormones and their receptors in assisted reproduction technology for patients with polycystic ovary syndrome.

Autor:	Koloda YA; Department of Obstetrics and Gynecology, Pediatric Faculty, FSBEI FPE 'Russian Medical Academy of Continuous Professional Education' of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation., Denisova YV; Department of Obstetrics and Gynecology, Pediatric Faculty, FSBEI FPE 'Russian Medical Academy of Continuous Professional Education' of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation., Podzolkova NM; Department of Obstetrics and Gynecology, Pediatric Faculty, FSBEI FPE 'Russian Medical Academy of Continuous Professional Education' of the Ministry of Healthcare of the Russian Federation, Moscow, Russian Federation.
Jazyk:	angličtina
Zdroj:	Drug metabolism and personalized therapy [Drug Metab Pers Ther] 2021 Dec 01; Vol. 37 (2), pp. 111-122. Date of Electronic Publication: 2021 Dec 01.
DOI:	10.1515/dmpt-2021-0123
Abstrakt:	Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies in women of childbearing, which is defined by the accumulation of multiple, small fluid-filled ovarian cysts without the selection of a single dominant follicle. Most PCOS phenotypes are characterized by the absence of spontaneous ovulation, resistance toward ovulation inductors, the production of a large immature oocytes number, and the high prevalence of ovarian hyperstimulation syndrome, resulting in reduced assisted reproductive technologies (ART) programs effectiveness. The review analyses current data about the relationship between polymorphism genotypes of KISS genes, follicle stimulating hormone ( FSH) , luteinizing hormone ( LH) , anti-Müllerian hormone ( AMH) and their receptors genes, gonadotropin-releasing hormone ( GnRH) , estrogen, and progesterone receptors genes, the PCOS risk and the features of ovarian response to stimulation during ART cycles. The use of single nucleotide polymorphisms (SNPs) as prognostic markers of ART programs outcomes would provide a personalized approach to the drugs and doses choice for ovarian stimulation and significantly increase the chance of pregnancy. (© 2021 Walter de Gruyter GmbH, Berlin/Boston.)
Databáze:	MEDLINE
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