Atopobiosis and Dysbiosis in Ocular Diseases: Is Fecal Microbiota Transplant and Probiotics a Promising Solution?
| Autor: | Gunardi TH; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Susantono DP; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Victor AA; Department of Ophthalmology, Dr. Cipto Mangunkusumo National General Hospital - Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia., Sitompul R; Department of Ophthalmology, Dr. Cipto Mangunkusumo National General Hospital - Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of ophthalmic & vision research [J Ophthalmic Vis Res] 2021 Oct 25; Vol. 16 (4), pp. 631-643. Date of Electronic Publication: 2021 Oct 25 (Print Publication: 2021). |
| DOI: | 10.18502/jovr.v16i4.9754 |
| Abstrakt: | Purpose: To highlight the role of atopobiosis and dysbiosis in the pathomechanism of autoimmune uveitis, therefore supporting fecal microbiota transplant (FMT) and probiotics as potential targeted-treatment for uveitis. Methods: This review synthesized literatures upon the relation between gut microbiota, autoimmune uveitis, FMT, and probiotics, published from January 2001 to March 2021 and indexed in PubMed, Google Scholar, CrossRef. Results: The basis of the gut-eye axis revolves around occurrences of molecular mimicry, increase in pro-inflammatory cytokines, gut epithelial barrier disruption, and translocation of microbes to distant sites. In patients with autoimmune uveitis, an increase of gut Fusobacterium and Enterobacterium were found. With current knowledge of aforementioned mechanisms, studies modifying the gut microbiome and restoring the physiologic gut barrier has been the main focus for pathomechanism-based therapy. In mice models, FMT and probiotics targeting repopulation of gut microbiota has shown significant improvement in clinical manifestations of uveitis. Consequently, a better understanding in the homeostasis of gut microbiome along with their role in the gut-eye axis is needed to develop practical targeted treatment. Conclusion: Current preliminary studies are promising in establishing a causative gut-eye axis relationship and the possibility of conducting FMT and probiotics as targeted treatment to mitigate autoimmune uveitis, to shorten disease duration, and to prevent further complications. Competing Interests: There are no conflicts of interest. (Copyright © 2021 Gunardi et al.) |
| Databáze: | MEDLINE |
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