| Autor: |
Mikhailova SV; Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 630090 Novosibirsk, Russia., Ivanoshchuk DE; Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), 630090 Novosibirsk, Russia.; Institute of Internal and Preventive Medicine-Branch of Institute of Cytology and Genetics, SB RAS, 630004 Novosibirsk, Russia. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of personalized medicine [J Pers Med] 2021 Nov 14; Vol. 11 (11). Date of Electronic Publication: 2021 Nov 14. |
| DOI: |
10.3390/jpm11111201 |
| Abstrakt: |
The main functions of adipose tissue are thought to be storage and mobilization of the body's energy reserves, active and passive thermoregulation, participation in the spatial organization of internal organs, protection of the body from lipotoxicity, and ectopic lipid deposition. After the discovery of adipokines, the endocrine function was added to the above list, and after the identification of crosstalk between adipocytes and immune cells, an immune function was suggested. Nonetheless, it turned out that the mechanisms underlying mutual regulatory relations of adipocytes, preadipocytes, immune cells, and their microenvironment are complex and redundant at many levels. One possible way to elucidate the picture of adipose-tissue regulation is to determine genetic variants correlating with obesity. In this review, we examine various aspects of adipose-tissue involvement in innate immune responses as well as variants of immune-response genes associated with obesity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
