Synthesis of Functional Building Blocks for Type III-B Rotaxane Dendrimer.

Autor: Kwan CS; State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, China., Ho WK; Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China., Chen Y; State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, China., Cai Z; State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, China., Leung KC; State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong, China.
Jazyk: angličtina
Zdroj: Polymers [Polymers (Basel)] 2021 Nov 12; Vol. 13 (22). Date of Electronic Publication: 2021 Nov 12.
DOI: 10.3390/polym13223909
Abstrakt: Second-generation type III-B rotaxane dendrons, equipped with succinimide and acetylene functional groups, were synthesized successfully and characterized by NMR spectroscopy and mass spectrometry. A cell viability study of a dendron with a normal cell line of L929 fibroblast cells revealed no obvious cytotoxicity at a range of 5 to 100 μM. The nontoxic properties of the sophisticated rotaxane dendron building blocks provided a choice of bio-compatible macromolecular machines that could be potentially developed into polymeric materials.
Databáze: MEDLINE
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