Total synthesis of (3R, 4S)-4-hydroxylasiodiplodin.

Autor: Sheelam K; Department of Chemistry, JNT University, Hyderabad, Telangana, India.; GVK Biosciences Private Limited, Hyderabad, Telangana, India., Chidara S; GVK Biosciences Private Limited, Hyderabad, Telangana, India., Vinnakota S; Department of Chemistry, Faculty of Science and Technology, ICFAI Foundation for Higher Education, Hyderabad, Telangana, India., Sridhar G; Department of Chemistry, Kakatiya Institute of Technology and Science, Warangal, India., Polothi R; Department of Chemistry, JNT University, Hyderabad, Telangana, India.; GVK Biosciences Private Limited, Hyderabad, Telangana, India.
Jazyk: angličtina
Zdroj: Natural product research [Nat Prod Res] 2023 Apr; Vol. 37 (8), pp. 1277-1283. Date of Electronic Publication: 2021 Nov 22.
DOI: 10.1080/14786419.2021.2003354
Abstrakt: An efficient stereoselective total synthesis of (3R, 4S)-4-hydroxylasiodiplodin has been accomplished starting from known starting materials. The key steps involved in this synthesis are Stille cross coupling, alkylation of 1,3-dithiane and Yamaguchi macrolactonization.
Databáze: MEDLINE