Whole-brain connectivity atlas of glutamatergic and GABAergic neurons in the mouse dorsal and median raphe nuclei.

Autor:	Xu Z; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China., Feng Z; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China.; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China., Zhao M; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China., Sun Q; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China., Deng L; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China., Jia X; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China., Jiang T; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China., Luo P; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China., Chen W; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China., Tudi A; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China., Yuan J; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China.; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China., Li X; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China.; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China., Gong H; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China.; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China.; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Science, Shanghai, China., Luo Q; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China.; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China.; School of Biomedical Engineering, Hainan University, Haikou, China., Li A; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, MoE Key Laboratory for Biomedical Photonics, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, China.; HUST-Suzhou Institute for Brainsmatics, JITRI, Suzhou, China.; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Science, Shanghai, China.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2021 Nov 18; Vol. 10. Date of Electronic Publication: 2021 Nov 18.
DOI:	10.7554/eLife.65502
Abstrakt:	The dorsal raphe nucleus (DR) and median raphe nucleus (MR) contain populations of glutamatergic and GABAergic neurons that regulate diverse behavioral functions. However, their whole-brain input-output circuits remain incompletely elucidated. We used viral tracing combined with fluorescence micro-optical sectioning tomography to generate a comprehensive whole-brain atlas of inputs and outputs of glutamatergic and GABAergic neurons in the DR and MR. We found that these neurons received inputs from similar upstream brain regions. The glutamatergic and GABAergic neurons in the same raphe nucleus had divergent projection patterns with differences in critical brain regions. Specifically, MR glutamatergic neurons projected to the lateral habenula through multiple pathways. Correlation and cluster analysis revealed that glutamatergic and GABAergic neurons in the same raphe nucleus received heterogeneous inputs and sent different collateral projections. This connectivity atlas further elucidates the anatomical architecture of the raphe nuclei, which could facilitate better understanding of their behavioral functions. Competing Interests: ZX, ZF, MZ, QS, LD, XJ, TJ, PL, WC, AT, JY, XL, HG, QL, AL No competing interests declared (© 2021, Xu et al.)
Databáze:	MEDLINE
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