Association of serum surfactant protein D and SFTPD gene variants with asthma in Danish children, adolescents, and young adults.

Autor: Hoffmann-Petersen B; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.; Open Patient Data Explorative Network, Odense University Hospital, Odense, Denmark.; Institute of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark., Suffolk R; Department of Pediatrics, Hospital of Southern Jutland, Aabenraa, Denmark., Petersen JJH; Department of Pediatrics, Hospital of Southern Jutland, Esbjerg, Denmark., Petersen TH; Department of Pediatrics, Hospital of Southern Jutland, Kolding, Denmark., Brasch-Andersen C; Department of Clinical Genetics, Odense University Hospital, Odense, Denmark., Høst A; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark., Halken S; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark., Sorensen GL; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark., Agertoft L; Hans Christian Andersen Children's Hospital, Odense University Hospital, Odense, Denmark.
Jazyk: angličtina
Zdroj: Immunity, inflammation and disease [Immun Inflamm Dis] 2022 Feb; Vol. 10 (2), pp. 189-200. Date of Electronic Publication: 2021 Nov 15.
DOI: 10.1002/iid3.560
Abstrakt: Background: Surfactant Protein D (SP-D) is a pattern recognition molecule belonging to the family of collectins expressed in multiple human organ systems, including the lungs. Previous studies have shown that SP-D levels in bronchoalveolar lavage samples decrease and serum levels increase in patients suffering from asthma, possibly due to a combination of induced SP-D synthesis and decreased air-blood barrier integrity. The aims of this study were to investigate whether serum levels of SP-D and common variants in the SP-D gene were associated with asthma in adolescents and young adults.
Methods: Prospective observational study including 449 adolescents and young adults (age 11-27 years) previously diagnosed with asthma during a 2-year period from 2003 to 2005 (0-16 years). At follow-up from 2016 to 2017, 314 healthy controls with no history of asthma were recruited. Serum SP-D was analyzed on samples obtained at baseline as well as samples obtained at follow-up. SP-D genotyping was performed for rs721917, rs2243639, and rs3088308.
Results: No differences were found in mean levels of sSP-D and SFTPD genotype among subjects with current asthma, no current asthma, and controls. Serum SP-D and SFTPD genotype were not associated with any clinical parameters of asthma. Furthermore, baseline sSP-D was not associated with asthma at follow-up.
Conclusion: Serum surfactant protein D and common SP-D gene variants were not associated with asthma in Danish adolescents and young adults with mild to moderate asthma. Serum surfactant protein D did not demonstrate any value as a clinical biomarker of asthma.
(© 2021 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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