Impact of non-alcoholic fatty liver disease on the risk of sarcopenia: a nationwide multicenter prospective study.

Autor: Roh E; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea., Hwang SY; Department of Biostatistics, Korea University College of Medicine, Seoul, Republic of Korea., Yoo HJ; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea., Baik SH; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea., Lee JH; Catholic Institute of U-Healthcare, The Catholic University of Korea, Seoul, Republic of Korea., Son SJ; Department of Psychiatry, Ajou University School of Medicine, Suwon, Republic of Korea., Kim HJ; Department of Family Medicine, Jeju National University School of Medicine, Jeju, Republic of Korea., Park YS; Department of Family Medicine, Hallym University Chuncheon Sacred Heart Hospital, Chuncheon, Republic of Korea., Lee SG; Department of Physical & Rehabilitation Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea., Cho BL; Department of Family Medicine, Center for Health Promotion and Optimal Aging, Seoul National University College of Medicine, Seoul, Republic of Korea., Jang HC; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Kim BJ; Department of Psychiatry, Gyeongsang National University College of Medicine, Jinju, Republic of Korea., Kim M; East-West Medical Research Institute, Kyung Hee University, Seoul, Republic of Korea., Won CW; Department of Family Medicine, College of Medicine, Kyung Hee University, Seoul, Republic of Korea. chunwon62@naver.com., Choi KM; Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea. medica7@gmail.com.
Jazyk: angličtina
Zdroj: Hepatology international [Hepatol Int] 2022 Jun; Vol. 16 (3), pp. 545-554. Date of Electronic Publication: 2021 Nov 15.
DOI: 10.1007/s12072-021-10258-8
Abstrakt: Background and Aims: Despite the association between sarcopenia and non-alcoholic fatty liver disease (NAFLD), no study has evaluated the predictive role of NAFLD in sarcopenia. We investigated impact of NAFLD on the risk of low muscle mass (LMM) and low muscle strength (LMS) in a nationwide multicenter study.
Methods: A total of 1595 community-dwelling people aged 70-84 years were followed for 2 years in the Korean Frailty and Aging Cohort Study. Muscle mass was estimated by dividing appendicular skeletal muscle mass (ASM) by body mass index (BMI). Muscle strength was measured as handgrip strength (HGS) divided by BMI. The sex-specific lowest quintiles of ASM/BMI and HGS/BMI of the study population were used as cutoffs for LMM and LMS, respectively. The risk of LMM and LMS were assessed according to hepatic steatosis index (HSI) and fatty liver index (FLI) quartiles.
Results: As HSI quartiles increased, the LMM risk increased gradually, after adjusting for age, sex, lifestyle factors, comorbidities, and several causative factors (insulin resistance, inflammation, and vitamin D) (Q4 vs. Q1 OR [95% CI] 3.46 [2.23-5.35]). The increased risk of LMS was even higher according to HSI quartiles (Q4 vs. Q1 5.81 [3.67-9.21]). Multivariate analyses based on FLI showed similar results. People with NAFLD (HSI > 36) were at higher risk of developing LMM and LMS compared to those without (1.65 [1.19-2.31] and 2.29 [1.61-3.26], respectively).
Conclusions: The presence of NAFLD may predict future risk of LMM and LMS, with greater impact on LMS than on LMM.
(© 2021. Asian Pacific Association for the Study of the Liver.)
Databáze: MEDLINE
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