Epidural Spinal Electrogram Provides Direct Spinal Recordings in Awake Human Participants.

Autor:	Burke JF; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States., Kunwar N; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States., Yaroshinsky MS; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States., Louie KH; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States., Shirvalkar P; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.; Department of Anesthesia and Pain Management, University of California, San Francisco, San Francisco, CA, United States.; Department of Neurology, University of California, San Francisco, San Francisco, CA, United States., Su P; Department of Anesthesia and Pain Management, University of California, San Francisco, San Francisco, CA, United States., Henry M; Department of Anesthesia and Pain Management, University of California, San Francisco, San Francisco, CA, United States., Pasvankas G; Department of Anesthesia and Pain Management, University of California, San Francisco, San Francisco, CA, United States., Poree L; Department of Anesthesia and Pain Management, University of California, San Francisco, San Francisco, CA, United States., Jacques L; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States., Wang DD; Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in human neuroscience [Front Hum Neurosci] 2021 Oct 26; Vol. 15, pp. 721076. Date of Electronic Publication: 2021 Oct 26 (Print Publication: 2021).
DOI:	10.3389/fnhum.2021.721076
Abstrakt:	Little is known about the electrophysiological activity of the spinal cord during voluntary movement control in humans. We present a novel method for recording electrophysiological activity from the human spinal cord using implanted epidural electrodes during naturalistic movements including overground walking. Spinal electrograms (SEGs) were recorded from epidural electrodes implanted as part of a test trial for patients with chronic pain undergoing evaluation for spinal cord stimulation. Externalized ends of the epidural leads were connected to an external amplifier to capture SEGs. Electromyographic and accelerometry data from the upper and lower extremities were collected using wireless sensors and synchronized to the SEG data. Patients were instructed to perform various arm and leg movements while SEG and kinematic data were collected. This study proves the safety and feasibility of performing epidural spinal recordings from human subjects performing movement tasks. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Burke, Kunwar, Yaroshinsky, Louie, Shirvalkar, Su, Henry, Pasvankas, Poree, Jacques and Wang.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu