Relationship between amikacin pharmacokinetics and biological parameters associated with organ dysfunction: a case series study of critically ill patients with intra-abdominal sepsis.

Autor:	Shahrami B; Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, The Islamic Republic of Iran., Sefidani Forough A; School of Clinical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia., Khezrnia SS; Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, The Islamic Republic of Iran., Najmeddin F; Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, The Islamic Republic of Iran., Arabzadeh AA; Department of Surgery, Ardabil University of Medical Sciences, Ardabil, The Islamic Republic of Iran., Rouini MR; Department of Pharmaceutics, Tehran University of Medical Sciences, Tehran, The Islamic Republic of Iran., Najafi A; Department of Anesthesiology and Critical Care, Tehran University of Medical Sciences, Tehran, The Islamic Republic of Iran., Mojtahedzadeh M; Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, The Islamic Republic of Iran mojtahed@sina.tums.ac.ir.
Jazyk:	angličtina
Zdroj:	European journal of hospital pharmacy : science and practice [Eur J Hosp Pharm] 2022 Mar; Vol. 29 (e1), pp. e72-e76. Date of Electronic Publication: 2021 Nov 11.
DOI:	10.1136/ejhpharm-2021-003089
Abstrakt:	Objectives: This study aimed to evaluate the relationship between amikacin pharmacokinetics and the biomarkers associated with organ dysfunction in critically ill patients with intra-abdominal sepsis. Methods: A case series involving critically ill patients with intra-abdominal sepsis who received an amikacin loading dose of 20-25 mg/kg intravenous infusion was studied. The 1-, 2-, 4-, 6- and 24-hour amikacin serum concentrations were measured to calculate the pharmacokinetic parameters. The Sequential Organ Failure Assessment (SOFA) score, white blood cells, neutrophil to lymphocyte ratio, platelet count, serum creatinine, creatinine clearance, bilirubin, partial pressure of oxygen to fraction of inspired oxygen ratio, serum albumin, procalcitonin, lactate level, erythrocyte sedimentation rate (ESR) and C-reactive protein were recorded. A linear regression analysis was performed to examine the relationship between the amikacin pharmacokinetics and the biological parameters. Results: Twenty-one patients were studied. A significant correlation was found between the volume of distribution and ESR (p<0.05, r=0.844). Moreover, drug clearance had a significant inverse correlation with serum lactate (p<0.05, r=-0.603). No other significant correlations were found. Conclusions: ESR and serum lactate were identified as useful predictors of amikacin pharmacokinetics in critically ill patients with intra-abdominal sepsis and may help guide the selection of appropriate empirical dosing. Competing Interests: Competing interests: None declared. (© European Association of Hospital Pharmacists 2022. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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