Intraoperative imaging in pathology-assisted surgery.

Autor: Voskuil FJ; Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Vonk J; Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van der Vegt B; Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Kruijff S; Department of Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., Ntziachristos V; Chair for Biological Imaging, Center for Translational Cancer Research, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany.; Institute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, Germany., van der Zaag PJ; Phillips Research Laboratories, Eindhoven, The Netherlands.; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.; Molecular Biophysics, Zernike Institute, University of Groningen, Groningen, The Netherlands., Witjes MJH; Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands., van Dam GM; Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. g.m.van.dam@umcg.nl.; AxelaRx/TRACER BV, Groningen, The Netherlands. g.m.van.dam@umcg.nl.
Jazyk: angličtina
Zdroj: Nature biomedical engineering [Nat Biomed Eng] 2022 May; Vol. 6 (5), pp. 503-514. Date of Electronic Publication: 2021 Nov 08.
DOI: 10.1038/s41551-021-00808-8
Abstrakt: The pathological assessment of surgical specimens during surgery can reduce the incidence of positive resection margins, which otherwise can result in additional surgeries or aggressive therapeutic regimens. To improve patient outcomes, intraoperative spectroscopic, fluorescence-based, structural, optoacoustic and radiological imaging techniques are being tested on freshly excised tissue. The specific clinical setting and tumour type largely determine whether endogenous or exogenous contrast is to be detected and whether the tumour specificity of the detected biomarker, image resolution, image-acquisition times or penetration depth are to be prioritized. In this Perspective, we describe current clinical standards for intraoperative tissue analysis and discuss how intraoperative imaging is being implemented. We also discuss potential implementations of intraoperative pathology-assisted surgery for clinical decision-making.
(© 2021. Springer Nature Limited.)
Databáze: MEDLINE
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