Right heart chambers geometry and function in patients with the atrial and the ventricular phenotypes of functional tricuspid regurgitation.

Autor:	Florescu DR; Department of Cardiology, University of Medicine and Pharmacy of Craiova, Strada Petru Rareș 2, Craiova 200349, Romania.; Department of Cardiac, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, S. Luca Hospital Piazzale Brescia 20, 20149 Milan, Italy.; Department of Physiology, University of Medicine and Pharmacy of Craiova, Strada Petru Rareș 2, Craiova 200349, Romania., Muraru D; Department of Cardiac, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, S. Luca Hospital Piazzale Brescia 20, 20149 Milan, Italy.; Department of Medicine and Surgery, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo, 1, 20126 Milano MI, Italy., Florescu C; Department of Cardiology, University of Medicine and Pharmacy of Craiova, Strada Petru Rareș 2, Craiova 200349, Romania., Volpato V; Department of Cardiac, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, S. Luca Hospital Piazzale Brescia 20, 20149 Milan, Italy.; Department of Medicine and Surgery, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo, 1, 20126 Milano MI, Italy., Caravita S; Department of Cardiac, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, S. Luca Hospital Piazzale Brescia 20, 20149 Milan, Italy., Perger E; Department of Cardiac, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, S. Luca Hospital Piazzale Brescia 20, 20149 Milan, Italy., Bălșeanu TA; Department of Physiology, University of Medicine and Pharmacy of Craiova, Strada Petru Rareș 2, Craiova 200349, Romania., Parati G; Department of Cardiac, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, S. Luca Hospital Piazzale Brescia 20, 20149 Milan, Italy.; Department of Medicine and Surgery, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo, 1, 20126 Milano MI, Italy., Badano LP; Department of Cardiac, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, S. Luca Hospital Piazzale Brescia 20, 20149 Milan, Italy.; Department of Medicine and Surgery, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo, 1, 20126 Milano MI, Italy.
Jazyk:	angličtina
Zdroj:	European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2022 Jun 21; Vol. 23 (7), pp. 930-940.
DOI:	10.1093/ehjci/jeab211
Abstrakt:	Aims: Atrial functional tricuspid regurgitation (A-FTR) is a recently defined phenotype of functional tricuspid regurgitation (FTR) associated with persistent/permanent atrial fibrillation. Differently from the classical ventricular form of FTR (V-FTR), patients with A-FTR might present with severely dilated right atrium and tricuspid annulus (TA), and with preserved right ventricular (RV) size and systolic function. However, the geometry and function of the right ventricle, right atrium, and TA in patients with A-FTR and V-FTR remain to be systematically evaluated. Accordingly, we sought to: (i) study the geometry and function of the right ventricle, right atrium, and TA in A-FTR by two- and three-dimensional transthoracic echocardiography; and (ii) compare them with those found in V-FTR. Methods and Results: We prospectively analysed 113 (44 men, age 68 ± 18 years) FTR patients (A-FTR = 55 and V-FTR = 58) that were compared to two groups of age- and sex-matched controls to develop the respective Z-scores. Severity of FTR was similar in A-FTR and V-FTR patients. Z-scores of RV size were significantly larger, and those of RV function were significantly lower in V-FTR than in A-FTR (P < 0.001 for all). The right atrium was significantly enlarged in both A-FTR and V-FTR compared to controls (P < 0.001, Z-scores > 2), with similar right atrial (RA) maximum volume (RAVmax) between A-FTR and V-FTR (P = 0.2). Whereas, the RA minimum volumes (RAVmin) were significantly larger in A-FTR than in V-FTR (P = 0.001). Conclusion: Despite similar degrees of FTR and RAVmax size, A-FTR patients show larger RAVmin and smaller TA areas than V-FTR patients. Conversely, V-FTR patients show dilated, more elliptic and dysfunctional right ventricle than A-FTR patients. (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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