Age-specific prevalence of human papillomavirus and abnormal cytology at baseline in a diverse statewide prospective cohort of individuals undergoing cervical cancer screening in Mississippi.

Autor: Clarke MA; Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, Maryland, USA., Risley C; Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, Maryland, USA.; School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA., Stewart MW; School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA., Geisinger KR; Walter Reed National Military Medical Center, Armed Forces Joint Pathology Center, Bethesda, Maryland, USA., Hiser LM; School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA., Morgan JC; School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA., Owens KJ; School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.; Center for Informatics & Analytics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Ayyalasomayajula K; School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.; Center for Informatics & Analytics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Rives RM; School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.; Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA., Jannela A; School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.; Center for Informatics & Analytics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Grunes DE; Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA., Zhang L; School of Nursing, University of Mississippi Medical Center, Jackson, Mississippi, USA.; Office of Health Data & Research, Mississippi State Department of Health, Jackson, Mississippi, USA., Schiffman M; Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, Maryland, USA., Wagner S; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland, USA., Boland J; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland, USA., Bass S; Cancer Genomics Research Laboratory, Division of Cancer Epidemiology and Genetics, NCI, Bethesda, Maryland, USA., Wentzensen N; Clinical Genetics Branch, Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, Maryland, USA.
Jazyk: angličtina
Zdroj: Cancer medicine [Cancer Med] 2021 Dec; Vol. 10 (23), pp. 8641-8650. Date of Electronic Publication: 2021 Nov 03.
DOI: 10.1002/cam4.4340
Abstrakt: Background: Mississippi (MS) has among the highest rates of cervical cancer incidence and mortality in the United States, with disproportionately higher rates among Blacks compared to Whites. Here, we evaluate the prevalence of high-risk human papillomavirus (HPV) and abnormal cytology in a representative baseline sample from a diverse statewide cohort of individuals attending cervical screening in MS from the STRIDES Study (STudying Risk to Improve DisparitiES in cervical cancer).
Methods: We included individuals aged 21-65 years undergoing screening at the University of Mississippi Medical Center (UMMC) and the Mississippi State Department of Health (MSDH) from May to November 2018. We calculated age-specific HPV prevalence, overall and by partial HPV16/18 genotyping, and abnormal cytology by race.
Results: A total of 6871 individuals (mean age 35.7 years) were included. HPV prevalence was 25.6% and higher in Blacks (28.0%) compared to Whites (22.4%). HPV prevalence was significantly higher in Blacks aged 21-24 years (50.2%) and 30-34 years (30.2%) compared to Whites in the same age groups (32.1% and 20.7%; p < 0.0001, respectively). The prevalence of high-grade cytologic abnormalities, a cytologic sign of cervical precancer, peaked earlier in Blacks (ages 25-29) compared to Whites (35-39). For comparison, we also analyzed HPV prevalence data from the National Health and Nutrition Examination Survey (NHANES, 2013-2016) and observed similar racial differences in HPV prevalence among women aged 21-24 years.
Conclusions: Our findings suggest that Blacks undergoing cervical cancer screening in MS have higher prevalence of other high-risk 12 HPV types at younger ages and experience an earlier peak of high-grade cytologic abnormalities compared to Whites.
(© 2021 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. This article has been contributed to by US Government employees and their work is in the public domain in the USA.)
Databáze: MEDLINE
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