Chemoprevention with a tea from hawthorn ( Crataegus oxyacantha ) leaves and flowers attenuates colitis in rats by reducing inflammation and oxidative stress.

Autor:	Nascimento RPD; School of Food Engineering, University of Campinas, Campinas, São Paulo, Brazil., Machado APDF; School of Food Engineering, University of Campinas, Campinas, São Paulo, Brazil., Lima VS; School of Food Engineering, University of Campinas, Campinas, São Paulo, Brazil.; Institute of Health and Biotechnology, Federal University of Amazonas, Coari, Amazonas, Brazil., Moya AMTM; School of Food Engineering, University of Campinas, Campinas, São Paulo, Brazil., Reguengo LM; School of Food Engineering, University of Campinas, Campinas, São Paulo, Brazil., Bogusz Junior S; Institute of Chemistry of São Carlos, University of São Paulo, São Carlos, São Paulo, Brazil., Leal RF; IBD Research Laboratory, Colorectal Surgery Unit, Surgery Dept, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Cao-Ngoc P; IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, France., Rossi JC; IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, France., Leclercq L; IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, France., Cottet H; IBMM, University of Montpellier, CNRS, ENSCM, Montpellier, France., Cazarin CBB; School of Food Engineering, University of Campinas, Campinas, São Paulo, Brazil., Marostica Junior MR; School of Food Engineering, University of Campinas, Campinas, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Food chemistry: X [Food Chem X] 2021 Oct 07; Vol. 12, pp. 100139. Date of Electronic Publication: 2021 Oct 07 (Print Publication: 2021).
DOI:	10.1016/j.fochx.2021.100139
Abstrakt:	The purpose of the study was to determine the effects of a tea from the leaves and flowers of Crataegus oxyacantha in rats with colitis. Colitis was induced by administration of 2,4,6-trinitrobenzene sulfonic acid. Hawthorn tea (HT) (100 mg/kg) was given via gavage for 21 days and the mesalamine drug (100 mg/kg) was administrated during the period of disease onset. HT was rich in total phenolic compounds (16.5%), flavonoids (1.8%), and proanthocyanidins (1.5%); vitexin-2-O-rhamnoside was the main compound detected. Mesalamine and the HT diminished the length of the lesions formed in the colon, in addition to reducing the levels of myeloperoxidase and interleukin-1β. Mesalamine was able to significantly reverse the body weight loss, while HT improved the activity of glutathione reductase and catalase. Histological scoring was not changed by the interventions, but it was highly correlated with the necrotic area. HT given at 100 mg/kg can be effective against colitis. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Authors.)
Databáze:	MEDLINE
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