The HO-1/CO System and Mitochondrial Quality Control in Skeletal Muscle.
| Autor: | Gasier HG; Department of Anesthesiology., Suliman HB, Piantadosi CA |
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| Jazyk: | angličtina |
| Zdroj: | Exercise and sport sciences reviews [Exerc Sport Sci Rev] 2022 Jan 01; Vol. 50 (1), pp. 49-55. |
| DOI: | 10.1249/JES.0000000000000277 |
| Abstrakt: | Inducible heme oxygenase (HO)-1 catalyzes the breakdown of heme to biliverdin, iron, and carbon monoxide (CO). CO binds to cytochrome c oxidase and alters mitochondrial redox balance and coordinately regulates mitochondrial quality control (MQC) during oxidant stress and inflammation. The hypothesis presented is that the skeletal muscle HO-1/CO system helps modulate components in the MQC cycle during metabolic stress. (Copyright © 2021 by the American College of Sports Medicine.) |
| Databáze: | MEDLINE |
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