Global and Regional Myocardial Work in Female Adolescents with Weight Disorders.

Autor: Paysal J; LAPEC EA4278 Laboratory, Avignon University, F-84000 Avignon, France.; Néonatologie et Réanimation Pédiatrique, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France., Merlin E; Pédiatrie, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France.; INSERM, CIC 1405, Unité CRECHE, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France., Rochette E; Pédiatrie, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France.; INSERM, CIC 1405, Unité CRECHE, Université Clermont Auvergne, F-63000 Clermont-Ferrand, France., Terral D; Pédiatrie, CHU Clermont-Ferrand, F-63000 Clermont-Ferrand, France., Nottin S; LAPEC EA4278 Laboratory, Avignon University, F-84000 Avignon, France.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2021 Oct 12; Vol. 10 (20). Date of Electronic Publication: 2021 Oct 12.
DOI: 10.3390/jcm10204671
Abstrakt: Background: Anorexia nervosa (AN) and obesity (OB) lead to changes in SBP (i.e., loading conditions) that may affect left ventricular (LV) myocardial work (MW). The novel concept of LV pressure-strain loops allows non-invasive estimation of MW, this latter being correlated with cardiac energy metabolism. In addition, the study of regional MW can detect subtle alterations in cardiac function by highlighting an abnormal distribution of MW.
Objective: The aim of this study was to assess the cardiac function of AN and OB patients by evaluating global and regional LV strains and MW.
Methods: Eighty-seven female adolescents, comprising 26 with AN (14.6 ± 1.9 yrs. old), 28 with OB (13.2 ± 1.4 yrs. old), and 33 controls (14.0 ± 2.0 yrs. old) underwent speckle-tracking echography to assess global and regional LV strains and MW.
Results: SBP was higher in adolescents with obesity than in AN patients or controls. Global MW was similar between groups. In AN patients and controls, longitudinal strains were higher at the apex than at the base of the LV, whereas they were similar in obesity patients, owing to a decrease in their apical longitudinal strain. Consequently, their MW was higher at the basal level than either of the other two groups (1854 ± 272 vs. 1501 ± 280 vs. 1575 ± 295 mmHg% in OB patients, AN patients, and controls, respectively.
Conclusion: Despite altered SBP, the global MW of adolescents with weight disorders was unaffected. However, in adolescents with obesity, the distribution of their regional LV MW was altered, which might reflect specific regional remodeling.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje