High parathyroid hormone levels after parathyroidectomy for parathyroid adenoma are not related to the cellularity of the remaining glands.
| Autor: | Sagiv R; Joyce & Irving Goldman Medical School Faculty of Health Sciences, Ben-Gurion University of the Negev Beer-Sheva Israel., Delgado B; Pathology Unit Soroka University Medical Center Beer-Sheva Israel., Sadeh R; Clinical Research Center of Soroka Medical Center Beer-Sheva Israel., Shashar S; Clinical Research Center of Soroka Medical Center Beer-Sheva Israel., Fraenkel M; Endocrinology Unit Soroka University Medical Center Beer-Sheva Israel., Yegodayev KM; Shraga Segal Department of Microbiology, Immunology, and Genetics Faculty of Health Sciences, Ben-Gurion University of the Negev Beer-Sheva Israel., Elkabets M; Shraga Segal Department of Microbiology, Immunology, and Genetics Faculty of Health Sciences, Ben-Gurion University of the Negev Beer-Sheva Israel., Joshua BZ; Department of Otorhinolaryngology - Head and Neck Surgery Barzilai Medical Center Ashkelon Israel. |
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| Jazyk: | angličtina |
| Zdroj: | Laryngoscope investigative otolaryngology [Laryngoscope Investig Otolaryngol] 2021 Sep 08; Vol. 6 (5), pp. 1220-1227. Date of Electronic Publication: 2021 Sep 08 (Print Publication: 2021). |
| DOI: | 10.1002/lio2.644 |
| Abstrakt: | Background: Patients with primary hyperparathyroidism (PHPT) treated surgically occasionally have normalized calcium, but persistently high parathyroid hormone (PTH). We hypothesized that a possible explanation for this phenomenon is an underlying hyperplasia rather than adenoma. Methods: Retrospective cohort of patients who underwent parathyroidectomy for PHPT with biopsy of a normal-appearing parathyroid gland were included. Cellularity level of each biopsy and of the adenoma's rim was determined. Results: Forty-seven patients were included. Of them, 19 (40%) had postoperative normocalcemia but elevated PTH. There was no correlation between cellularity either in the rim or of the normal-appearing parathyroid gland and postoperative PTH. The postoperative high PTH group had higher preoperative PTH ( P = 0.001) and larger adenomas ( P = 0.025). Conclusions: High PTH levels after successful parathyroidectomy in patients with primary hyperparathyroidism do not appear to result from underlying hyperplasia. A possible alternative explanation is that these patients have a higher preoperative burden of disease. Competing Interests: The authors declare no potential conflict of interest. (© 2021 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC on behalf of The Triological Society.) |
| Databáze: | MEDLINE |
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