Changing places: Chromosomal Passenger Complex relocation in early anaphase.

Autor: Hadders MA; Oncode Institute and Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Lens SMA; Oncode Institute and Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands. Electronic address: s.m.a.lens@umcutrecht.nl.
Jazyk: angličtina
Zdroj: Trends in cell biology [Trends Cell Biol] 2022 Feb; Vol. 32 (2), pp. 165-176. Date of Electronic Publication: 2021 Oct 16.
DOI: 10.1016/j.tcb.2021.09.008
Abstrakt: The Chromosomal Passenger Complex (CPC) regulates a plethora of processes during multiple stages of nuclear and cytoplasmic division. Early during mitosis, the CPC is recruited to centromeres and kinetochores, and ensures that the duplicated chromosomes become properly connected to microtubules from opposite poles of the mitotic spindle. Progression into anaphase is accompanied by a striking relocation of the CPC from centromeres to the antiparallel microtubule overlaps of the anaphase spindle and to the equatorial cortex. This translocation requires direct interactions of the CPC with the kinesin-6 family member MKLP2/KIF20A, and the inactivation of cyclin B-cyclin-dependent kinase-1 (CDK1). Here, we review recent progress in the regulation of this relocation event. Furthermore, we discuss why the CPC must be relocated during early anaphase in light of recent advances in the functions of the CPC post metaphase.
Competing Interests: Declaration of interests None declared by authors.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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