Hematopoietic Stem Cell Mobilization: Current Collection Approaches, Stem Cell Heterogeneity, and a Proposed New Method for Stem Cell Transplant Conditioning.

Autor: Menendez-Gonzalez JB; Center for Cancer Research, Center For Transplantation Sciences, Massachusetts General Hospital, Boston, MA, USA., Hoggatt J; Center for Cancer Research, Center For Transplantation Sciences, Massachusetts General Hospital, Boston, MA, USA. hoggatt.jonathan@mgh.harvard.edu.
Jazyk: angličtina
Zdroj: Stem cell reviews and reports [Stem Cell Rev Rep] 2021 Dec; Vol. 17 (6), pp. 1939-1953. Date of Electronic Publication: 2021 Oct 18.
DOI: 10.1007/s12015-021-10272-1
Abstrakt: Hematopoietic stem cells naturally traffic out of their bone marrow niches into the peripheral blood. This natural trafficking process can be enhanced with numerous pharmacologic agents - a process termed "mobilization" - and the mobilized stem cells can be collected for transplantation. We review the current state of mobilization with an update on recent clinical trials and new biologic mechanisms regulating stem cell trafficking. We propose that hematopoietic mobilization can be used to answer questions regarding hematopoietic stem cell heterogeneity, can be used for non-toxic conditioning of patients receiving stem cell transplants, and can enhance gene editing and gene therapy strategies to cure genetic diseases.
(© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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