Interferon-λ Improves the Efficacy of Intranasally or Rectally Administered Influenza Subunit Vaccines by a Thymic Stromal Lymphopoietin-Dependent Mechanism.

Autor:	Ye L; Department of Immunology, International Cancer Center, Shenzhen University Health Science Center, Shenzhen, China.; Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany., Schnepf D; Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany., Ohnemus A; Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany., Ong LC; Department of Microbiology and Immunology, University of Gothenburg, Gothenburg, Sweden., Gad HH; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Hartmann R; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Lycke N; Department of Microbiology and Immunology, University of Gothenburg, Gothenburg, Sweden., Staeheli P; Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.
Jazyk:	angličtina
Zdroj:	Frontiers in immunology [Front Immunol] 2021 Sep 29; Vol. 12, pp. 749325. Date of Electronic Publication: 2021 Sep 29 (Print Publication: 2021).
DOI:	10.3389/fimmu.2021.749325
Abstrakt:	Previous work showed that interferon-λ (IFN-λ) can trigger the synthesis of thymic stromal lymphopoietin (TSLP) by specialized epithelial cells in the upper airways of mice, thereby improving the performance of intranasally administered influenza vaccines. Here we demonstrate that protein-only influenza vaccines containing either IFN-λ or TSLP boosted antigen-specific IgG1 and IgA responses and enhanced the resistance of mice to influenza virus challenge, irrespective of whether the vaccines were applied via the intranasal or the rectal route. TSLP receptor deficiency negatively influenced vaccine-induced antiviral immunity by impairing the migration of dendritic cells from the airways to the draining lymph nodes of immunized mice, thereby restraining follicular helper T cell and germinal center B cell responses. As previously observed during intranasal vaccination, the adjuvant effect of IFN-λ on a rectally administered influenza vaccine was no longer observed when TSLP receptor-deficient mice were used for immunization, highlighting the central role of the IFN-λ/TSLP axis for vaccine-induced antiviral immunity in the mucosa. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Ye, Schnepf, Ohnemus, Ong, Gad, Hartmann, Lycke and Staeheli.)
Databáze:	MEDLINE
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