Acute White Matter Integrity Post-trauma and Prospective Posttraumatic Stress Disorder Symptoms.

Autor:	Weis CN; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, United States., Huggins AA; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, United States., Miskovich TA; Sacramento VA Medical Center (VHA), Sacramento, CA, United States., Fitzgerald JM; Department of Psychology, Marquette University, Milwaukee, WI, United States., Bennett KP; Montana VA Health Care System, Helena, MT, United States., Krukowski JL; Department of Psychology, Marquette University, Milwaukee, WI, United States., Webb EK; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, United States., deRoon-Cassini TA; Division of Trauma and Acute Care Surgery, Department of Surgery, Medical College of Wisconsin, Milwaukee, WI, United States., Larson CL; Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, WI, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in human neuroscience [Front Hum Neurosci] 2021 Sep 29; Vol. 15, pp. 742198. Date of Electronic Publication: 2021 Sep 29 (Print Publication: 2021).
DOI:	10.3389/fnhum.2021.742198
Abstrakt:	Background: Little is known about what distinguishes those who are resilient after trauma from those at risk for developing posttraumatic stress disorder (PTSD). Previous work indicates white matter integrity may be a useful biomarker in predicting PTSD. Research has shown changes in the integrity of three white matter tracts-the cingulum bundle, corpus callosum (CC), and uncinate fasciculus (UNC)-in the aftermath of trauma relate to PTSD symptoms. However, few have examined the predictive utility of white matter integrity in the acute aftermath of trauma to predict prospective PTSD symptom severity in a mixed traumatic injury sample. Method: Thus, the current study investigated acute brain structural integrity in 148 individuals being treated for traumatic injuries in the Emergency Department of a Level 1 trauma center. Participants underwent diffusion-weighted magnetic resonance imaging 2 weeks post-trauma and completed several self-report measures at 2-weeks (T1) and 6 months (T2), including the Clinician Administered PTSD Scale for DSM-V (CAPS-5), post-injury. Results: Consistent with previous work, T1 lesser anterior cingulum fractional anisotropy (FA) was marginally related to greater T2 total PTSD symptoms. No other white matter tracts were related to PTSD symptoms. Conclusions: Results demonstrate that in a traumatically injured sample with predominantly subclinical PTSD symptoms at T2, acute white matter integrity after trauma is not robustly related to the development of chronic PTSD symptoms. These findings suggest the timing of evaluating white matter integrity and PTSD is important as white matter differences may not be apparent in the acute period after injury. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Weis, Huggins, Miskovich, Fitzgerald, Bennett, Krukowski, Webb, deRoon-Cassini and Larson.)
Databáze:	MEDLINE
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