Visual processing and BDNF levels in first-episode schizophrenia.

Autor: Shoshina II; Pavlov Institute of Physiology, Russian Academy of Science, Department of Visual Physiology, Saint-Petersburg, Russian Federation; St. Petersburg State University, Department of Liberal Arts and Sciences, Saint-Petersburg, Russian Federation., Hovis JK; School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada., Felisberti FM; Department of Psychology, Kingston University London, London, United Kingdom., Santos NA; Department of Psychology, Federal University of Paraiba, Joao Pessoa, Brazil; Perception, Neuroscience and Behaviour Laboratory, Federal University of Paraiba, Brazil., Adreeva A; St. Petersburg State University, Department of Liberal Arts and Sciences, Saint-Petersburg, Russian Federation., Butler PD; Nathan Kline Institute for Psychiatric Research, Orangeburg, NY, United States; Department of Psychiatry, New York University School of Medicine, NY, USA., Fernandes TP; Department of Psychology, Federal University of Paraiba, Joao Pessoa, Brazil; Perception, Neuroscience and Behaviour Laboratory, Federal University of Paraiba, Brazil. Electronic address: thiagompfernandes@gmail.com.
Jazyk: angličtina
Zdroj: Psychiatry research [Psychiatry Res] 2021 Nov; Vol. 305, pp. 114200. Date of Electronic Publication: 2021 Sep 01.
DOI: 10.1016/j.psychres.2021.114200
Abstrakt: Previous studies have shown that patients diagnosed with schizophrenia (SCZ) have deficits in early visual processing, namely contrast processing. The brain-derived neurotropic factor (BDNF) is an important measure to investigate neuroplasticity in some visual functions like visual perception. In this study, we investigated the relationship between visual processing and BDNF levels in first-episode SCZ patients. Thirty-nine healthy controls and 43 first-episode SCZ patients were enrolled. Contrast sensitivity measurements were conducted using low, mid- and high spatial frequencies. First-episode SCZ patients had higher contrast sensitivity than healthy controls for all frequencies, except for the middle spatial frequency. Negative correlations were found between BDNF, contrast sensitivity and clinical variables, mostly for middle and high spatial frequencies among females. Our results provide support for (i) the association of SCZ with alterations of magno- and parvocellular pathway functioning and (ii) decreased BDNF levels in first-episode SCZ patients. This study highlights the importance of using biomarkers along with other measures to investigate visual processing in SCZ and other disorders.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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