Left atrial strain predicts incident atrial fibrillation in the general population: the Copenhagen City Heart Study.

Autor:	Hauser R; Department of Cardiology, Herlev and Gentofte University Hospital, Kildegårdsvej 28, 2900 Copenhagen, Denmark., Nielsen AB; Department of Cardiology, Herlev and Gentofte University Hospital, Kildegårdsvej 28, 2900 Copenhagen, Denmark., Skaarup KG; Department of Cardiology, Herlev and Gentofte University Hospital, Kildegårdsvej 28, 2900 Copenhagen, Denmark., Lassen MCH; Department of Cardiology, Herlev and Gentofte University Hospital, Kildegårdsvej 28, 2900 Copenhagen, Denmark., Duus LS; Department of Cardiology, Herlev and Gentofte University Hospital, Kildegårdsvej 28, 2900 Copenhagen, Denmark., Johansen ND; Department of Cardiology, Herlev and Gentofte University Hospital, Kildegårdsvej 28, 2900 Copenhagen, Denmark., Sengeløv M; Department of Cardiology, Herlev and Gentofte University Hospital, Kildegårdsvej 28, 2900 Copenhagen, Denmark., Marott JL; The Copenhagen City Heart Study, Bispebjerg and Frederiksberg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark., Jensen G; The Copenhagen City Heart Study, Bispebjerg and Frederiksberg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark., Schnohr P; The Copenhagen City Heart Study, Bispebjerg and Frederiksberg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark., Søgaard P; The Copenhagen City Heart Study, Bispebjerg and Frederiksberg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark.; Department of Cardiology, Aalborg University Hospital, Hobrovej 18-22, 9100 Aalborg, Denmark.; Institute of Clinical Medicine, Faculty of Medicine, University of Aalborg, Aalborg, Denmark., Møgelvang R; The Copenhagen City Heart Study, Bispebjerg and Frederiksberg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark.; Department of Cardiology, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.; Cardiovascular Research Unit, University of Southern Denmark, Baagøes Allé 15, 5700 Svendborg, Denmark.; Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark., Biering-Sørensen T; Department of Cardiology, Herlev and Gentofte University Hospital, Kildegårdsvej 28, 2900 Copenhagen, Denmark.; The Copenhagen City Heart Study, Bispebjerg and Frederiksberg University Hospital, Bispebjerg Bakke 23, 2400 Copenhagen, Denmark.; Institute of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen, Denmark.
Jazyk:	angličtina
Zdroj:	European heart journal. Cardiovascular Imaging [Eur Heart J Cardiovasc Imaging] 2021 Dec 18; Vol. 23 (1), pp. 52-60.
DOI:	10.1093/ehjci/jeab202
Abstrakt:	Background: Left atrial (LA) strain parameters have been demonstrated to be valuable predictors of atrial fibrillation (AF) in several patient cohorts. The purpose of this study was to investigate whether LA strain, assessed by two-dimensional speckle-tracking echocardiography, can be used to predict the development of AF in the general population. Methods and Results: This prospective longitudinal study included 4466 participants from the fifth Copenhagen City Heart Study. All participants underwent a health examination, including echocardiographic measurements of LA strain. Participants with prevalent AF at baseline were excluded. The primary endpoint was incident AF. During a median follow-up period of 5.3 years, 154 (4.3%) participants developed AF. In univariable analysis, peak atrial longitudinal strain (PALS), peak atrial contraction strain (PACS), and LA strain during the conduit phase were significantly associated with the development of AF. PALS [hazard ratio (HR) 1.05, 95% confidence interval (CI) (1.03-1.07), P < 0.001, per 1% decrease] and PACS (HR 1.08, 95% CI (1.05-1.12), P < 0.001, per 1% decrease] remained independent predictors of AF in multivariable analysis. In addition, PALS and PACS remained significantly associated with AF development even in participants with normal-sized atria and normal left ventricular (LV) systolic function. Conclusion: In the general population, PALS and PACS independently predict incident AF. These findings remained consistent even in participants with normal-sized LA and normal LV systolic function. (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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