Correlations between dynamic contrast-enhanced magnetic resonance imaging parameters and histopathologic factors in breast cancer.

Autor:	Tuan Linh L; Department of Radiology, Ha Noi Medical University Hospital, Ha Noi, Viet Nam.; Department of Radiology, Ha Noi Medical University, Ha Noi, Viet Nam., Minh Duc N; Department of Radiology, Ha Noi Medical University, Ha Noi, Viet Nam.; Department of Radiology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam.; Department of Radiology, Children's Hospital 2, Ho Chi Minh City, Viet Nam., Tra My TT; Department of Radiology, Ha Noi Medical University, Ha Noi, Viet Nam., Viet Bang L; Department of Pathology, Tam Anh General Hospi-tal, Ha Noi, Viet Nam., Minh Thong P; Department of Radiology, Ha Noi Medical University, Ha Noi, Viet Nam.; Department of Radiology, Bach Mai Hospital, Ha Noi, Viet Nam.
Jazyk:	angličtina
Zdroj:	La Clinica terapeutica [Clin Ter] 2021 Sep 29; Vol. 172 (5), pp. 453-460.
DOI:	10.7417/CT.2021.2358
Abstrakt:	Background: This study aimed to correlate dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters with prognostic factors in breast cancer. Methods: A retrospective analysis was performed in 45 patients who had breast DCE-MRI and were diagnosed with invasive ductal breast cancer following surgery. The following DCE-MRI parameters were calculated: percentage of initial peak enhancement (Epeak), time to initial peak enhancement (TTP), initial slope increase (IS), early signal enhancement ratio (ESER), and time-signal intensity curve (TIC) types. Correlations between Epeak, TTP, IS, ESER, and prognostic factors were determined using the Mann-Whitney U test and the Kruskal-Wallis test. The Chi-square test and Fisher's exact test were used to investigate the relationship between kinetic curve types and prognostic factors. Results: Epeak and IS were significantly higher in the Ki-67 high-expression group than in the Ki-67 low-expression group (p = 0.031 and p = 0.012, respectively). ESER was significantly correlated with the histological type and Ki-67 expression level (p = 0.014 and p = 0.047, respectively). The TIC types were significantly correlated with the Ki-67 expression level (p = 0.009). Tumors with plateaus and washout curves were more likely to be associated with the Ki-67 high-expression group than tumors with a persistent curve (P = 0.027 and P = 0.038, respectively). TTP had no correlation with any prognostic factors (P > 0.05). Conclusions: This study showed that the DCE-MRI parameters of breast cancer were correlated with the expression of histopathological prognostic factors and might be useful for predicting prognosis.
Databáze:	MEDLINE
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