Predicted Vitamin D Status and Colorectal Cancer Incidence in the Black Women's Health Study.

Autor:	Barber LE; Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts., Bertrand KA; Slone Epidemiology Center at Boston University, Boston, Massachusetts., Petrick JL; Slone Epidemiology Center at Boston University, Boston, Massachusetts., Gerlovin H; U.S. Department of Veterans Affairs, Boston, Massachusetts., White LF; Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts., Adams-Campbell LL; Georgetown Lombardi Comprehensive Cancer Center, Washington, District of Columbia., Rosenberg L; Slone Epidemiology Center at Boston University, Boston, Massachusetts., Roy HK; Department of Medicine, Baylor College of Medicine, Houston, Texas., Palmer JR; Slone Epidemiology Center at Boston University, Boston, Massachusetts. jpalmer@bu.edu.
Jazyk:	angličtina
Zdroj:	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2021 Dec; Vol. 30 (12), pp. 2334-2341. Date of Electronic Publication: 2021 Oct 07.
DOI:	10.1158/1055-9965.EPI-21-0675
Abstrakt:	Background: Observational studies, mostly among White populations, suggest that low vitamin D levels increase colorectal cancer risk. African Americans, who are disproportionately burdened by colorectal cancer, often have lower vitamin D levels compared with other populations. Methods: We assessed predicted vitamin D score in relation to colorectal cancer among 49,534 participants in the Black Women's Health Study, a cohort of African American women followed from 1995 to 2017 through biennial questionnaires. We derived predicted vitamin D scores at each questionnaire cycle for all participants using a previously validated prediction model based on actual 25-hydroxyvitamin D values from a subset of participants. We calculated cumulative average predicted vitamin D score at every cycle by averaging scores from cycles up to and including that cycle. Using Cox proportional hazards regression, we estimated hazard ratios (HR) and 95% confidence intervals (CI) for colorectal cancer incidence according to predicted score quartiles. Results: Over follow-up, 488 incident colorectal cancers occurred. Compared with women in the highest quartile of predicted vitamin D score, those in the lowest had an estimated 41% (HR = 1.41; 95% CI, 1.05-1.90) higher colorectal cancer risk. Comparable HRs were 1.44 (95% CI, 1.02-2.01) for colon and 1.34 (95% CI, 0.70-2.56) for rectal cancer. Conclusions: Low vitamin D status may lead to elevated colorectal cancer risk in African American women. Impact: Our findings, taken together with established evidence that vitamin D levels are generally lower in African Americans than other U.S. groups, suggest that low vitamin D status may contribute to the disproportionately high colorectal cancer incidence among African Americans. (©2021 American Association for Cancer Research.)
Databáze:	MEDLINE
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