| Autor: |
Quintal-Martínez JP; Faculty of Chemical Engineering, Autonomous University of Yucatán, Merida, Yucatan, Mexico., Quintal-Ortiz IG; Hematology Laboratory, Dr. Hideyo Noguchi Regional Research Center, Merida, Yucatan, Mexico., Alonzo-Salomón LG; Hematology Laboratory, Dr. Hideyo Noguchi Regional Research Center, Merida, Yucatan, Mexico., Muñoz-Rodríguez D; Faculty of Chemical Engineering, Autonomous University of Yucatán, Merida, Yucatan, Mexico., Segura-Campos MR; Faculty of Chemical Engineering, Autonomous University of Yucatán, Merida, Yucatan, Mexico. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal food [J Med Food] 2021 Dec; Vol. 24 (12), pp. 1304-1312. Date of Electronic Publication: 2021 Oct 06. |
| DOI: |
10.1089/jmf.2021.0008 |
| Abstrakt: |
In Mexico, Cnidoscolus aconitifolius (chaya) has been used to treat cardiovascular diseases (CVD). Because CVD are the number one cause of mortality, chaya use has become a health strategy. The aim of this study was to evaluate the antithrombotic activity and identify the metabolites in the most active extract. Aqueous (Aq), ethanolic (EtOH), acetonic (An), ethyl acetate (AcOEt), diethyl ether (Et 2 O), and hexanic (Hx) extracts were obtained. Platelet aggregation, phospholipase A 2 , prothrombin time (PT), activated partial thromboplastin time (aPTT), and clot lysis were evaluated. Metabolites were identified by gas chromatography-mass spectrometry (GC-MS). EtOH showed the greatest inhibition of platelet aggregation and phospholipase A 2 . Ac had the greatest effect on PT and aPTT. AcOEt had the greatest effect on clot lysis. EtOH, with the highest potential, was analyzed by GC-MS; fatty acids and triterpenes were identified. Thus, EtOH showed greater antiplatelet activity and other extracts showed moderate activity. This is a preliminary antithrombotic study. Future research will allow the development of nutraceuticals or functional ingredients for the prevention and treatment of thrombosis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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