Putting the Pieces Together: the Hair Cell Transduction Complex.

Autor: Holt JR; Departments of Otolaryngology & Neurology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115, USA. jeffrey.holt@childrens.harvard.edu., Tobin M; Laboratoire Physico-Chimie Curie, Institut Curie, Université PSL, Sorbonne Université, CNRS UMR168, Paris, 75005, France.; Departments of Otorhinolaryngology, Neuroscience and Neurology, University of Pennsylvania, Philadelphia, PA, 19104, USA., Elferich J; Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA., Gouaux E; Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA.; Howard Hughes Medical Institute, Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR, 97239, USA., Ballesteros A; Molecular Physiology and Biophysics Section, Disorders and Stroke, National Institute of Neurological, National Institutes of Health, Bethesda, MD, 20892, USA., Yan Z; Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, 518132, China., Ahmed ZM; Department of Otolaryngology Head & Neck Surgery, School of Medicine, University of Maryland, Baltimore, MD, 21201, USA., Nicolson T; Department of Otolaryngology-Head & Neck Surgery, Stanford University, Stanford, CA, USA.
Jazyk: angličtina
Zdroj: Journal of the Association for Research in Otolaryngology : JARO [J Assoc Res Otolaryngol] 2021 Dec; Vol. 22 (6), pp. 601-608. Date of Electronic Publication: 2021 Oct 06.
DOI: 10.1007/s10162-021-00808-0
Abstrakt: Identification of the components of the mechanosensory transduction complex in hair cells has been a major research interest for many auditory and vestibular scientists and has attracted attention from outside the field. The past two decades have witnessed a number of significant advances with emergence of compelling evidence implicating at least a dozen distinct molecular components of the transduction machinery. Yet, how the pieces of this ensemble fit together and function in harmony to enable the senses of hearing and balance has not been clarified. The goal of this review is to summarize a 2021 symposium presented at the annual mid-winter meeting of the Association for Research in Otolaryngology. The symposium brought together the latest insights from within and beyond the field to examine individual components of the transduction complex and how these elements interact at molecular, structural, and biophysical levels to gate mechanosensitive channels and initiate sensory transduction in the inner ear. The review includes a brief historical background to set the stage for topics to follow that focus on structure, properties, and interactions of proteins such as CDH23, PCDH15, LHFPL5, TMIE, TMC1/2, and CIB2/3. We aim to present the diversity of ideas in this field and highlight emerging theories and concepts. This review will not only provide readers with a deeper appreciation of the components of the transduction apparatus and how they function together, but also bring to light areas of broad agreement, areas of scientific controversy, and opportunities for future scientific discovery.
(© 2021. Association for Research in Otolaryngology.)
Databáze: MEDLINE
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