The Role of Oxidative Stress and Antioxidant Balance in Pregnancy.

Autor:	Hussain T; College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128 Hunan, China.; Animal Science Division, Nuclear Institute for Agriculture and Biology College, Pakistan Institute of Engineering and Applied Sciences (NIAB-C, PIEAS), Faisalabad 38000, Pakistan., Murtaza G; Department of Animal Reproduction, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Sindh 70050, Pakistan., Metwally E; Department of Cytology & Histology, Faculty of Veterinary Medicine, Suez Canal University, Ismailia, Egypt., Kalhoro DH; Department of Veterinary Microbiology, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Sindh 70050, Pakistan., Kalhoro MS; Department of Animal Products Technology, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Sindh 70050, Pakistan., Rahu BA; Department of Animal Reproduction, Faculty of Animal Husbandry and Veterinary Sciences, Sindh Agriculture University, Tandojam, Sindh 70050, Pakistan., Sahito RGA; Institute of Neurophysiology, University of Cologne, Cologne 50931, Germany., Yin Y; Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125 Hunan, China., Yang H; Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China., Chughtai MI; Animal Science Division, Nuclear Institute for Agriculture and Biology College, Pakistan Institute of Engineering and Applied Sciences (NIAB-C, PIEAS), Faisalabad 38000, Pakistan., Tan B; College of Animal Science and Technology, Hunan Agricultural University, Changsha, 410128 Hunan, China.
Jazyk:	angličtina
Zdroj:	Mediators of inflammation [Mediators Inflamm] 2021 Sep 27; Vol. 2021, pp. 9962860. Date of Electronic Publication: 2021 Sep 27 (Print Publication: 2021).
DOI:	10.1155/2021/9962860
Abstrakt:	It has been widely known that oxidative stress disrupts the balance between reactive oxygen species (ROS) and the antioxidant system in the body. During pregnancy, the physiological generation of ROS is involved in a variety of developmental processes ranging from oocyte maturation to luteolysis and embryo implantation. While abnormal overproduction of ROS disrupts these processes resulting in reproductive failure. In addition, excessive oxidative stress impairs maternal and placental functions and eventually results in fetal loss, IUGR, and gestational diabetes mellitus. Although some oxidative stress is inevitable during pregnancy, a balancing act between oxidant and antioxidant production is necessary at different stages of the pregnancy. The review aims to highlight the importance of maintaining oxidative and antioxidant balance throughout pregnancy. Furthermore, we highlight the role of oxidative stress in pregnancy-related diseases. Competing Interests: All authors have no any conflict of interest. (Copyright © 2021 Tarique Hussain et al.)
Databáze:	MEDLINE
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