Usefulness of Immunoglobulin A in Patients With Decompensated Heart Failure: Is It a Future Marker of Congestion? Preliminary Experience.

Autor: López-Vilella R; Heart Failure and Transplant Unit, La Fe University and Polytechnic Hospital, Valencia, Spain; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain. Electronic address: lopez_raqvil@gva.es., Martín PA; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain., Trenado VD; Heart Failure and Transplant Unit, La Fe University and Polytechnic Hospital, Valencia, Spain; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain., Sánchez-Lázaro I; Heart Failure and Transplant Unit, La Fe University and Polytechnic Hospital, Valencia, Spain; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain., Ezzitouny M; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain., Pastor PJ; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain., Solé JM; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain., Edo SL; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain., Dolz LM; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain., Bonet LA; Heart Failure and Transplant Unit, La Fe University and Polytechnic Hospital, Valencia, Spain; Department of Cardiology, La Fe University and Polytechnic Hospital, Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain; University of Valencia, Valencia, Spain.
Jazyk: angličtina
Zdroj: Transplantation proceedings [Transplant Proc] 2021 Nov; Vol. 53 (9), pp. 2706-2709. Date of Electronic Publication: 2021 Sep 29.
DOI: 10.1016/j.transproceed.2021.07.051
Abstrakt: Background: The purpose of this study was to analyze whether the level of IgA is related to right ventricular function and systemic congestion in patients with decompensated heart failure (HF) and reduced ejection fraction (EF).
Methods: This was a consecutive prospective and observational study of hospitalized patients diagnosed with decompensated HF with reduced EF. The recruitment period lasted 2 months. In the first 24 hours after admission, clinical assessment, general laboratory tests, determination of HF biomarkers, IgA and echocardiographic study were performed. Patients were classified into 2 groups according to whether the plasma IgA level was lower (n = 11) or higher than 300 mg/dL (n = 12).
Results: Significant differences in IgA levels were found in the peripheral congestion variables (no congestion: 232, interquartile range [IQR], 125-310 mg/dL vs congestion: 429, IQR, 308-520 mg/dL; P = .03). There were also differences in echocardiographic parameters of right ventricular function, with a greater deterioration of right ventricular function in the group with higher IgA levels (P < .05). There was a highly significant correlation between tricuspid annulus systolic excursion values and IgA levels (P = .004).
Conclusions: In decompensated HF, patients with greater clinical congestion and echocardiographic parameters of right ventricular dysfunction have higher plasma IgA levels. This study is a preliminary experience that will help to establish the basis of the cardiointestinal syndrome as a clinical picture of systemic congestion in HF.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: