| Autor: |
Crisi PE; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy., Luciani A; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy., Di Tommaso M; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy., Prasinou P; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy., De Santis F; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy., Chatgilialoglu C; ISOF, Consiglio Nazionale delle Ricerche, 40129 Bologna, Italy., Pietra M; Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Ozzano dell'Emilia, 40064 Bologna, Italy., Procoli F; Ospedale Veterinario I Portoni Rossi, Zola Predosa, 40069 Bologna, Italy., Sansone A; ISOF, Consiglio Nazionale delle Ricerche, 40129 Bologna, Italy., Giordano MV; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy., Gramenzi A; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy., Ferreri C; ISOF, Consiglio Nazionale delle Ricerche, 40129 Bologna, Italy., Boari A; Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Teramo, 64100 Teramo, Italy. |
| Abstrakt: |
Canine chronic enteropathies (CEs) are inflammatory processes resulting from complex interplay between the mucosal immune system, intestinal microbiome, and dietary components in susceptible dogs. Fatty acids (FAs) play important roles in the regulation of physiologic and metabolic pathways and their role in inflammation seems to be dual, as they exhibit pro-inflammatory and anti-inflammatory functions. Analysis of red blood cell (RBC) membrane fatty acid profile represents a tool for assessing the quantity and quality of structural and functional molecular components. This study was aimed at comparing the FA membrane profile, determined by Gas Chromatography and relevant lipid parameter of 48 CE dogs compared with 68 healthy dogs. In CE patients, the levels of stearic ( p < 0.0001), dihomo-gamma-linolenic, eicosapentaenoic ( p = 0.02), and docosahexaenoic ( p = 0.02) acids were significantly higher, and those of palmitic ( p < 0.0001) and linoleic ( p = 0.0006) acids were significantly lower. Non-responder dogs presented higher percentages of vaccenic acid ( p = 0.007), compared to those of dogs that responded to diagnostic trials. These results suggest that lipidomic status may reflect the "gut health", and the non-invasive analysis of RBC membrane might have the potential to become a candidate biomarker in the evaluation of dogs affected by CE. |
