Age distribution and mortality associated with intussusception in children under two years of age in nine sentinel surveillance hospitals in Zambia, 2007-2018.

Autor:	Mpabalwani EM; University of Zambia, School of Medicine, Department of Paediatrics & Child Health, Lusaka, Zambia.; University Teaching Hospitals, Children´s Hospital, Lusaka, Zambia., Bvulani B; University Teaching Hospitals, Adult Hospital, Department of Surgery, Paediatric Surgical Unit, Lusaka, Zambia., Simwaka J; University Teaching Hospitals, Adult Hospital, Virology Laboratory, Lusaka, Zambia., Chitambala P; University Teaching Hospitals, Adult Hospital, Department of Surgery, Paediatric Surgical Unit, Lusaka, Zambia., Matapo B; World Health Organisation, Regional Office for Africa, Zambia & Congo Brazzaville., Tate J; World Health Organisation, Regional Office for Africa, Zambia & Congo Brazzaville., Parashar U; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA., Mwenda J; World Health Organisation, Regional Office for Africa, Zambia & Congo Brazzaville.
Jazyk:	angličtina
Zdroj:	The Pan African medical journal [Pan Afr Med J] 2021 Jul 28; Vol. 39 (Suppl 1), pp. 6. Date of Electronic Publication: 2021 Jul 28 (Print Publication: 2021).
DOI:	10.11604/pamj.supp.2021.39.1.26671
Abstrakt:	Introduction: recipients of monovalent rotavirus vaccine have a low risk of developing intussusception (IS) in high- to medium-high-income countries. In sub-Saharan Africa, Zambia included, this risk of IS has not been assessed. Two-dose monovalent rotavirus vaccine, introduced in Zambia in 2012 in the capital of Lusaka, and rolled out countrywide in 2013, is administered at 6 and 10 weeks of age with no catch-up dose. Active IS surveillance monitoring in children < 2 years has been ongoing in Zambia since July 2009 and additional retrospective review was conducted from 2007- June 2009. Methods: retrospective review (January 2007-June 2009) and prospective (July 2009-December 2018) IS surveillance was conducted at nine hospitals and four large paediatric hospital departments in Zambia, respectively. Demographic and clinical data were collected from medical folder abstraction and supplemented by parental interview during prospective surveillance. Results: a total of 248 children < 2 years with IS were identified; 57.3% were male. Most cases with IS were infants (85.5%). IS admissions remained stable during the surveillance period with no seasonality pattern although an increase in cases occurred between August and October, hot dry season. The median time from symptom onset to presentation for treatment was 2 days and 63.6% (154/242) of IS diagnoses were made during surgery. The bowel resection rate was 46.6%. A high CFR of 23.3% was observed. Conclusion: the number of intussusception cases in Zambia was relatively small and remained stable over the 12-year study period. However, a high CFR was observed among cases. Competing Interests: The authors declare no competing interests. (©Evans Mwila Mpabalwani et al.)
Databáze:	MEDLINE
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