Intracellular Activity of Antibiotics against Coxiella burnetii in a Model of Activated Human THP-1 Cells.

Autor:	Peyrusson F; Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvaingrid.7942.8, Brussels, Belgium., Whelan AO; Defence Science and Technology Laboratorygrid.417845.b, Salisbury, United Kingdom., Hartley MG; Defence Science and Technology Laboratorygrid.417845.b, Salisbury, United Kingdom., Norville IH; Defence Science and Technology Laboratorygrid.417845.b, Salisbury, United Kingdom., Harding SV; Defence Science and Technology Laboratorygrid.417845.b, Salisbury, United Kingdom., Van Bambeke F; Pharmacologie cellulaire et moléculaire, Louvain Drug Research Institute, Université catholique de Louvaingrid.7942.8, Brussels, Belgium.
Jazyk:	angličtina
Zdroj:	Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2021 Nov 17; Vol. 65 (12), pp. e0106121. Date of Electronic Publication: 2021 Sep 20.
DOI:	10.1128/AAC.01061-21
Abstrakt:	We evaluated antibiotic activity against the intracellular bacterium Coxiella burnetii using an activated THP-1 cell model of infection. At clinically relevant concentrations, the intracellular bacterial load was reduced 300-fold by levofloxacin and finafloxacin, 40-fold by doxycycline, and 4-fold by ciprofloxacin and was unaffected by azithromycin. Acidification of the culture medium reduced antibiotic activity, with the exceptions of doxycycline (no change) and finafloxacin (slight improvement). This model may be used to select antibiotics to be evaluated in vivo .
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu