Polyphenols affect the humoral response in cancer, infectious and allergic diseases and autoimmunity by modulating the activity of T H 1 and T H 2 cells.

Autor: Benvenuto M; Saint Camillus International University of Health and Medical Sciences, Via di Sant'Alessandro 8, 00131 Rome, Italy; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Focaccetti C; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy; Department of Human Science and Promotion of the Quality of Life, San Raffaele University Rome, Via di Val Cannuta 247, 00166 Rome, Italy., Ciuffa S; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Fazi S; Department of Experimental Medicine, University of Rome 'Sapienza', Viale Regina Elena 324, 00161 Rome, Italy., Bei A; Medical School, University of Rome 'Tor Vergata', 00133 Rome, Italy., Miele MT; Department of Experimental Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Albonici L; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy., Cifaldi L; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy; Academic Department of Pediatrics (DPUO), Ospedale Pediatrico Bambino Gesù, IRCCS, Piazza Sant'Onofrio 4, 00165 Rome, Italy., Masuelli L; Department of Experimental Medicine, University of Rome 'Sapienza', Viale Regina Elena 324, 00161 Rome, Italy., Bei R; Department of Clinical Sciences and Translational Medicine, University of Rome 'Tor Vergata', Via Montpellier 1, 00133 Rome, Italy. Electronic address: bei@med.uniroma2.it.
Jazyk: angličtina
Zdroj: Current opinion in pharmacology [Curr Opin Pharmacol] 2021 Oct; Vol. 60, pp. 315-330. Date of Electronic Publication: 2021 Sep 11.
DOI: 10.1016/j.coph.2021.08.005
Abstrakt: Polyphenols are a wide class of natural substances, pleiotropic molecules capable of modulating several processes, involved in the humoral and cellular immune response. The activation, differentiation of B cells, and production of antibodies to protein antigens by plasma cells depend on T helper (T H ) CD4 + cells and secreted cytokines. Cancer, infectious, allergic, and autoimmune diseases are characterized by an imbalance of T H 1/T H 2 immunity and abnormal activation of the humoral response. Accordingly, polyphenols modulate the T H 1/T H 2 ratio, the secretion of multiple cytokines, the levels of antibodies, and therefore could contribute to recovering the state of health in these diseases. In this review, we summarize the current knowledge on the effects of polyphenols in modulating the humoral response in cancer, infectious and allergic diseases and in autoimmunity by affecting the activity of T H 1 and T H 2 cells.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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