The Human Connectome Project: A retrospective.

Autor: Elam JS; Washington University School of Medicine, St. Louis, MO, USA., Glasser MF; Washington University School of Medicine, St. Louis, MO, USA., Harms MP; Washington University School of Medicine, St. Louis, MO, USA., Sotiropoulos SN; Sir Peter Mansfield Imaging Centre & NIHR Nottingham Biomedical Research Centre, Queen's Medical Centre, School of Medicine, University of Nottingham, UK; Wellcome Centre for Integrative Neuroimaging, University of Oxford, UK., Andersson JLR; Wellcome Centre for Integrative Neuroimaging, University of Oxford, UK., Burgess GC; Washington University School of Medicine, St. Louis, MO, USA., Curtiss SW; Washington University School of Medicine, St. Louis, MO, USA., Oostenveld R; Donders Institute for Brain, Cognition and Behaviour, Radboud University, the Netherlands., Larson-Prior LJ; University of Arkansas for Medical Sciences, Little Rock, AR, USA., Schoffelen JM; Donders Institute for Brain, Cognition and Behaviour, Radboud University, the Netherlands., Hodge MR; Washington University School of Medicine, St. Louis, MO, USA., Cler EA; Washington University School of Medicine, St. Louis, MO, USA., Marcus DM; Washington University School of Medicine, St. Louis, MO, USA., Barch DM; Washington University School of Medicine, St. Louis, MO, USA., Yacoub E; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA., Smith SM; Wellcome Centre for Integrative Neuroimaging, University of Oxford, UK., Ugurbil K; Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA., Van Essen DC; Washington University School of Medicine, St. Louis, MO, USA. Electronic address: vanessen@wustl.edu.
Jazyk: angličtina
Zdroj: NeuroImage [Neuroimage] 2021 Dec 01; Vol. 244, pp. 118543. Date of Electronic Publication: 2021 Sep 08.
DOI: 10.1016/j.neuroimage.2021.118543
Abstrakt: The Human Connectome Project (HCP) was launched in 2010 as an ambitious effort to accelerate advances in human neuroimaging, particularly for measures of brain connectivity; apply these advances to study a large number of healthy young adults; and freely share the data and tools with the scientific community. NIH awarded grants to two consortia; this retrospective focuses on the "WU-Minn-Ox" HCP consortium centered at Washington University, the University of Minnesota, and University of Oxford. In just over 6 years, the WU-Minn-Ox consortium succeeded in its core objectives by: 1) improving MR scanner hardware, pulse sequence design, and image reconstruction methods, 2) acquiring and analyzing multimodal MRI and MEG data of unprecedented quality together with behavioral measures from more than 1100 HCP participants, and 3) freely sharing the data (via the ConnectomeDB database) and associated analysis and visualization tools. To date, more than 27 Petabytes of data have been shared, and 1538 papers acknowledging HCP data use have been published. The "HCP-style" neuroimaging paradigm has emerged as a set of best-practice strategies for optimizing data acquisition and analysis. This article reviews the history of the HCP, including comments on key events and decisions associated with major project components. We discuss several scientific advances using HCP data, including improved cortical parcellations, analyses of connectivity based on functional and diffusion MRI, and analyses of brain-behavior relationships. We also touch upon our efforts to develop and share a variety of associated data processing and analysis tools along with detailed documentation, tutorials, and an educational course to train the next generation of neuroimagers. We conclude with a look forward at opportunities and challenges facing the human neuroimaging field from the perspective of the HCP consortium.
Competing Interests: Declaration of Competing Interest The authors declare that they have no conflicts of interest in relation to this manuscript.
(Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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