Health related quality of life following open versus minimally invasive total gastrectomy for cancer: Results from a randomized clinical trial.

Autor: van der Wielen N; Department of Gastrointestinal Surgery, Amsterdam University Medical Center Location VU University Medical Center, Amsterdam, the Netherlands. Electronic address: ni.vanderwielen@amsterdamumc.nl., Daams F; Department of Gastrointestinal Surgery, Amsterdam University Medical Center Location VU University Medical Center, Amsterdam, the Netherlands., Rosati R; Department of Surgery, San Raffaele Hospital, Milan, Italy., Parise P; Department of Surgery, San Raffaele Hospital, Milan, Italy., Weitz J; Department of of Visceral, Thoracic and Vascular Surgery, University Hospital Carl Gustav Carus, Dresden, Germany., Reissfelder C; Department of Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Germany., Diez Del Val I; Department of Surgery, Hospital Universitario de Basurto, Bilbao, Spain., Loureiro C; Department of Surgery, Hospital Universitario de Basurto, Bilbao, Spain., Parada-González P; Department of Surgery, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain., Pintos-Martínez E; Department of Surgery, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain., Vallejo FM; Department of Surgery, Hospital de Jerez, Jerez de La Frontera, Spain., Achirica CM; Department of Surgery, Hospital de Jerez, Jerez de La Frontera, Spain., Sánchez-Pernaute A; Department of Surgery, Hospital Clínico San Carlos, Madrid, Spain., Campos AR; Department of Surgery, Hospital Clínico San Carlos, Madrid, Spain., Bonavina L; Department of Surgery, IRCCS Policlinico San Donato University Hospital, Milan, Italy., Asti ELG; Department of Surgery, IRCCS Policlinico San Donato University Hospital, Milan, Italy., Poza AA; Department of Surgery, Hospital Del Sureste, Madrid, Spain., Gilsanz C; Department of Surgery, Hospital Del Sureste, Madrid, Spain., Nilsson M; Division of Surgery, Department of Clinical Science Intervention and Technology, Karolinska Institutet and Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden., Lindblad M; Division of Surgery, Department of Clinical Science Intervention and Technology, Karolinska Institutet and Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden., Gisbertz SS; Department of Surgery, Amsterdam UMC, Location AMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands., van Berge Henegouwen MI; Department of Surgery, Amsterdam UMC, Location AMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, the Netherlands., Romario UF; Digestive Surgery, European Institute of Oncology, IRCCS, Milan, Italy., De Pascale S; Digestive Surgery, European Institute of Oncology, IRCCS, Milan, Italy., Akhtar K; Department of Surgery, Salford Royal NHS Foundation Trust, Manchester, UK., Bonjer HJ; Department of Gastrointestinal Surgery, Amsterdam University Medical Center Location VU University Medical Center, Amsterdam, the Netherlands., Cuesta MA; Department of Gastrointestinal Surgery, Amsterdam University Medical Center Location VU University Medical Center, Amsterdam, the Netherlands., van der Peet DL; Department of Gastrointestinal Surgery, Amsterdam University Medical Center Location VU University Medical Center, Amsterdam, the Netherlands., Straatman J; Department of Gastrointestinal Surgery, Amsterdam University Medical Center Location VU University Medical Center, Amsterdam, the Netherlands; Department of Clinical Epidemiology, Amsterdam University Medical Center, Amsterdam, the Netherlands.
Jazyk: angličtina
Zdroj: European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology [Eur J Surg Oncol] 2022 Mar; Vol. 48 (3), pp. 553-560. Date of Electronic Publication: 2021 Aug 30.
DOI: 10.1016/j.ejso.2021.08.031
Abstrakt: Introduction: Minimally invasive techniques show improved short-term and comparable long-term outcomes compared to open techniques in the treatment of gastric cancer and improved survival has been seen with the implementation of multimodality treatment. Therefore, focus of research has shifted towards optimizing treatment regimens and improving quality of life.
Materials and Methods: A randomized trial was performed in thirteen hospitals in Europe. Patients were randomized between open total gastrectomy (OTG) or minimally invasive total gastrectomy (MITG) after neoadjuvant chemotherapy. This study investigated patient reported outcome measures (PROMs) on health-related quality of life (HRQoL) following OTG or MITG, using the Euro-Qol-5D (EQ-5D) and the European Organization for Research and Treatment of Cancer (EORTC) questionnaires, modules C30 and STO22. Due to multiple testing a p-value < 0.001 was deemed statistically significant.
Results: Between January 2015 and June 2018, 96 patients were included in this trial. Forty-nine patients were randomized to OTG and 47 to MITG. A response compliance of 80% was achieved for all PROMs. The EQ5D overall health score one year after surgery was 85 (60-90) in the open group and 68 (50-83.8) in the minimally invasive group (P = 0.049). The median EORTC-QLQ-C30 overall health score one year postoperatively was 83,3 (66,7-83,3) in the open group and 58,3 (35,4-66,7) in the minimally invasive group (P = 0.002). This was not statistically significant.
Conclusion: No differences were observed between open total gastrectomy and minimally invasive total gastrectomy regarding HRQoL data, collected using the EQ-5D, EORTC QLQ-C30 and EORTC-QLQ-STO22 questionnaires.
(Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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