Polymyalgia rheumatica: A case series from Colombia and analysis of Latin America.

Autor:	Toro-Gutiérrez CE; Centro de Referencia en Osteoporosis, Reumatología & Dermatología, Cali, Colombia., Cañas CA; Rheumatology Unit, Fundación Valle Del Lili, Cali, Colombia., Mantilla RD; Dermatology and Rheumatology Foundation (FUNINDERMA), Bogota, Colombia., Beltrán S; Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia., Pastrana-Gonzalez V; Centro de Referencia en Osteoporosis, Reumatología & Dermatología, Cali, Colombia., Vecino MJ; Rheumatology Unit, Fundación Valle Del Lili, Cali, Colombia., Rodriguez-Jimenez M; Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia., Rojas M; Center for Autoimmune Diseases Research (CREA), School of Medicine and Health Sciences, Universidad del Rosario, Bogota, Colombia.
Jazyk:	angličtina
Zdroj:	Journal of translational autoimmunity [J Transl Autoimmun] 2021 Aug 21; Vol. 4, pp. 100115. Date of Electronic Publication: 2021 Aug 21 (Print Publication: 2021).
DOI:	10.1016/j.jtauto.2021.100115
Abstrakt:	Objective: Polymyalgia rheumatica (PMR) is the most common inflammatory disease in patients over 50 years. Information about the disease in Latin America (LATAM) is scarce. We aimed to evaluate a group of Colombian patients with PMR and to conduct a systematic review of PMR in LATAM. Methods: A multicentric retrospective study was performed. Medical records of 256 PMR patients were evaluated. Patients were divided into two groups, those fulfilling the 2012 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for PMR and those who did not (i.e., clinical diagnosis). A systematic literature review and meta regression was performed comparing Colombian vs LATAM patients. Results: From 256 patients, 145 (56.6%) fulfilled the 2012 EULAR/ACR criteria, and 111 (43.3%) were classified by clinical diagnosis. Inflammatory bilateral shoulder pain, pelvic girdle aching, morning stiffness >45 min, elevated erythrocyte sedimentation rate (ESR), and C-reactive protein (CPR), and Methotrexate (MTX) prescription were more common in the 2012 EULAR/ACR group. None of the included patients presented overt polyautoimmunity (PolyA), whereas up to 24% exhibited latent PolyA. In addition, these patients showed high frequency of malignancy (7.59%). In the meta regression analysis, Colombian patients exhibited lower ESR levels, and were less likely to develop giant cell arteritis (GCA) as compared to the rest of LATAM data. Conclusion: Patients with PMR in LATAM exhibit similar phenotypes from other cohorts worldwide. Malignancy, GCA and latent PolyA should be considered in the routine clinical follow-up of patients with PMR. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Authors. Published by Elsevier B.V.)
Databáze:	MEDLINE
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