The naked truth: a comprehensive clarification and classification of current 'myths' in naked mole-rat biology.

Autor: Buffenstein R; Calico Life Sciences LLC, 1170 Veterans Blvd, South San Francisco, CA, 94080, U.S.A., Amoroso V; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, 60607, U.S.A., Andziak B; Graduate Center City University of New York, 365 Fifth Avenue, New York, NY, 10016, U.S.A., Avdieiev S; Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, 33612, U.S.A., Azpurua J; Department of Anesthesiology, Stony Brook University, 101 Nicolls Road, Stony Brook, NY, 11794, U.S.A., Barker AJ; Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str 10, Berlin-Buch, 13092, Germany., Bennett NC; Mammal Research Institute, Department of Zoology and Entomology, University of Pretoria, Pretoria, 0002, South Africa., Brieño-Enríquez MA; Department of Obstetrics, Gynecology & Reproductive Medicine, Magee-Womens Research Institute, 204 Craft Avenue, Pittsburgh, PA, 15213, U.S.A., Bronner GN; Department Biological Sciences, Rondebosch, Cape Town, 7701, South Africa., Coen C; Reproductive Neurobiology, Division of Women's Health, School of Medicine, King's College London, Westminster Bridge Road, London, SE1 7EH, U.K., Delaney MA; Zoological Pathology Program, University of Illinois, 3505 Veterinary Medicine Basic Sciences Building, 2001 S Lincoln Avenue, Urbana, IL, 6180, U.S.A., Dengler-Crish CM; Department of Pharmaceutical Sciences, Northeast Ohio Medical University, 4209 State Route 44, Rootstown, OH, 44272, U.S.A., Edrey YH; Northwest Vista College, 3535 N. Ellison Drive, San Antonio, TX, 78251, U.S.A., Faulkes CG; School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, U.K., Frankel D; School of Engineering, Newcastle University, Merz Court, Newcastle Upon Tyne, NE1 7RU, U.K., Friedlander G; Université Paris Descartes, Faculté de Médecine, 12 Rue de l'École de Médecine, Paris, 5006, France., Gibney PA; Cornell University College of Veterinary Medicine, Ithaca, NY, 14853, U.S.A., Gorbunova V; Departments of Biology, University of Rochester, 402 Hutchison Hall, Rochester, NY, 14627, U.S.A., Hine C; Cleveland Clinic, Lerner Research Institute, 9500 Euclid Avenue, Cleveland, OH, 44195, U.S.A., Holmes MM; Department of Psychology, University of Toronto Mississauga, 3359 Mississauga Road North, Mississauga, ON, L5L 1C6, Canada., Jarvis JUM; Department Biological Sciences, Rondebosch, Cape Town, 7701, South Africa., Kawamura Y; Department of Aging and Longevity Research, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-0811, Japan., Kutsukake N; Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies, Hayama, 240-0193, Japan., Kenyon C; Calico Life Sciences LLC, 1170 Veterans Blvd, South San Francisco, CA, 94080, U.S.A., Khaled WT; The School of the Biological Sciences, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, U.K., Kikusui T; Companion Animal Research, School of Veterinary Medicine, Azabu University, Sagamihara, 252-5201, Japan., Kissil J; Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL, 33458, U.S.A., Lagestee S; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, 60607, U.S.A., Larson J; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, 60607, U.S.A., Lauer A; Department of Otolaryngology, Johns Hopkins School of Medicine, Baltimore, MD, 21205, U.S.A., Lavrenchenko LA; A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 119071, Russia., Lee A; Graduate Center City University of New York, 365 Fifth Avenue, New York, NY, 10016, U.S.A., Levitt JB; Biology Department, The City College of New York, 138th Street and Convent Avenue, New York, NY, 10031, U.S.A., Lewin GR; Max Delbrück Center for Molecular Medicine, Robert-Rössle-Str 10, Berlin-Buch, 13092, Germany., Lewis Hardell KN; Calico Life Sciences LLC, 1170 Veterans Blvd, South San Francisco, CA, 94080, U.S.A., Lin TD; Calico Life Sciences LLC, 1170 Veterans Blvd, South San Francisco, CA, 94080, U.S.A., Mason MJ; The School of the Biological Sciences, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, U.K., McCloskey D; College of Staten Island in the City University of New York, 2800 Victory Blvd, Staten Island, NY, 10314, U.S.A., McMahon M; Calico Life Sciences LLC, 1170 Veterans Blvd, South San Francisco, CA, 94080, U.S.A., Miura K; Department of Aging and Longevity Research, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-0811, Japan., Mogi K; Companion Animal Research, School of Veterinary Medicine, Azabu University, Sagamihara, 252-5201, Japan., Narayan V; Calico Life Sciences LLC, 1170 Veterans Blvd, South San Francisco, CA, 94080, U.S.A., O'Connor TP; The Rockefeller University, 1230 York Avenue, New York, NY, 10065, U.S.A., Okanoya K; Department of Life Sciences, The University of Tokyo, 7-3-1 Hongo, Tokyo, 153-8902, Japan., O'Riain MJ; Department Biological Sciences, Rondebosch, Cape Town, 7701, South Africa., Park TJ; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, 60607, U.S.A., Place NJ; Cornell University College of Veterinary Medicine, Ithaca, NY, 14853, U.S.A., Podshivalova K; Calico Life Sciences LLC, 1170 Veterans Blvd, South San Francisco, CA, 94080, U.S.A., Pamenter ME; Biology Department, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N 6N5, Canada., Pyott SJ; Groningen Department of Otorhinolaryngology, University Medical Center, Postbus 30.001, Groningen, RB, 9700, The Netherlands., Reznick J; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University Hospital Cologne, Joseph-Stelzmann-Street 26, Cologne, 50931, Germany., Ruby JG; Calico Life Sciences LLC, 1170 Veterans Blvd, South San Francisco, CA, 94080, U.S.A., Salmon AB; Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, 4939 Charles Katz Dr., San Antonio, TX, 78229, U.S.A., Santos-Sacchi J; Department of Neuroscience, Yale University School of Medicine, 200 South Frontage Road, SHM C-303, New Haven, CT, 06510, U.S.A., Sarko DK; Department of Anatomy, School of Medicine, Southern Illinois University, 975 S. Normal, Carbondale, IL, 62901, U.S.A., Seluanov A; Departments of Biology, University of Rochester, 402 Hutchison Hall, Rochester, NY, 14627, U.S.A., Shepard A; Department of Cancer Biology, The Scripps Research Institute, Scripps Florida, Jupiter, FL, 33458, U.S.A., Smith M; Calico Life Sciences LLC, 1170 Veterans Blvd, South San Francisco, CA, 94080, U.S.A., Storey KB; Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, K1S 5B6, Canada., Tian X; Department of Genetics - Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, U.S.A., Vice EN; Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL, 60607, U.S.A., Viltard M; Fondation pour la recherche en Physiologie, Université Catholique de Louvain, Clos Chapelle-aux-Champs 30, Woluwe-saint Lambert, 1200, Belgium., Watarai A; Companion Animal Research, School of Veterinary Medicine, Azabu University, Sagamihara, 252-5201, Japan., Wywial E; Biology Department, The City College of New York, 138th Street and Convent Avenue, New York, NY, 10031, U.S.A., Yamakawa M; Department of Evolutionary Studies of Biosystems, The Graduate University for Advanced Studies, Hayama, 240-0193, Japan., Zemlemerova ED; A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 119071, Russia., Zions M; Graduate Center City University of New York, 365 Fifth Avenue, New York, NY, 10016, U.S.A., Smith ESJ; The School of the Biological Sciences, University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, U.K.
Jazyk: angličtina
Zdroj: Biological reviews of the Cambridge Philosophical Society [Biol Rev Camb Philos Soc] 2022 Feb; Vol. 97 (1), pp. 115-140. Date of Electronic Publication: 2021 Sep 03.
DOI: 10.1111/brv.12791
Abstrakt: The naked mole-rat (Heterocephalus glaber) has fascinated zoologists for at least half a century. It has also generated considerable biomedical interest not only because of its extraordinary longevity, but also because of unusual protective features (e.g. its tolerance of variable oxygen availability), which may be pertinent to several human disease states, including ischemia/reperfusion injury and neurodegeneration. A recent article entitled 'Surprisingly long survival of premature conclusions about naked mole-rat biology' described 28 'myths' which, those authors claimed, are a 'perpetuation of beautiful, but falsified, hypotheses' and impede our understanding of this enigmatic mammal. Here, we re-examine each of these 'myths' based on evidence published in the scientific literature. Following Braude et al., we argue that these 'myths' fall into four main categories: (i) 'myths' that would be better described as oversimplifications, some of which persist solely in the popular press; (ii) 'myths' that are based on incomplete understanding, where more evidence is clearly needed; (iii) 'myths' where the accumulation of evidence over the years has led to a revision in interpretation, but where there is no significant disagreement among scientists currently working in the field; (iv) 'myths' where there is a genuine difference in opinion among active researchers, based on alternative interpretations of the available evidence. The term 'myth' is particularly inappropriate when applied to competing, evidence-based hypotheses, which form part of the normal evolution of scientific knowledge. Here, we provide a comprehensive critical review of naked mole-rat biology and attempt to clarify some of these misconceptions.
(© 2021 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.)
Databáze: MEDLINE
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