Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection.

Autor: Smith N; Translational Immunology Lab, Institut Pasteur, Paris, France., Goncalves P; Innate Immunity Unit, Institut Pasteur, INSERM U1223, Paris, France., Charbit B; Cytometry and Biomarkers UTechS, Institut Pasteur, Paris, France., Grzelak L; Virus and Immunity Unit, Institut Pasteur, Paris, France.; Sorbonne Paris Cité, Université de Paris, Paris, France., Beretta M; Humoral Immunology Laboratory, Institut Pasteur, INSERM U1222, Paris, France., Planchais C; Humoral Immunology Laboratory, Institut Pasteur, INSERM U1222, Paris, France., Bruel T; Virus and Immunity Unit, Institut Pasteur, Paris, France., Rouilly V; DATACTIX, Paris, France., Bondet V; Translational Immunology Lab, Institut Pasteur, Paris, France., Hadjadj J; Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Université de Paris, Paris, France.; Imagine Institute, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, Université de Paris, Paris, France., Yatim N; Translational Immunology Lab, Institut Pasteur, Paris, France.; Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Université de Paris, Paris, France., Pere H; Unité de Génomique Fonctionnelle des Tumeurs Solides, Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France., Merkling SH; Insect-Virus Interactions Unit, Institut Pasteur, CNRS UMR2000, Paris, France., Ghozlane A; Hub de Bioinformatique et Biostatistique, Institut Pasteur, Paris, France., Kernéis S; Equipe Mobile d'Infectiologie, Hôpital Cochin, AP-HP, APHP-CUP, Paris, France.; Université de Paris, INSERM, IAME, Paris, France.; Epidemiology and Antimicrobial Resistance Modeling Laboratory, Institut Pasteur, Paris, France., Rieux-Laucat F; Imagine Institute, Laboratory of Immunogenetics of Pediatric Autoimmune Diseases, INSERM UMR 1163, Université de Paris, Paris, France., Terrier B; Department of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Assistance Publique Hôpitaux de Paris-Centre (APHP-CUP), Université de Paris, Paris, France., Schwartz O; Virus and Immunity Unit, Institut Pasteur, Paris, France., Mouquet H; Humoral Immunology Laboratory, Institut Pasteur, INSERM U1222, Paris, France., Duffy D; Translational Immunology Lab, Institut Pasteur, Paris, France. darragh.duffy@pasteur.fr., Di Santo JP; Innate Immunity Unit, Institut Pasteur, INSERM U1223, Paris, France. james.di-santo@pasteur.fr.
Jazyk: angličtina
Zdroj: Nature immunology [Nat Immunol] 2021 Nov; Vol. 22 (11), pp. 1428-1439. Date of Electronic Publication: 2021 Sep 01.
DOI: 10.1038/s41590-021-01028-7
Abstrakt: Coordinated local mucosal and systemic immune responses following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection either protect against coronavirus disease 2019 (COVID-19) pathologies or fail, leading to severe clinical outcomes. To understand this process, we performed an integrated analysis of SARS-CoV-2 spike-specific antibodies, cytokines, viral load and bacterial communities in paired nasopharyngeal swabs and plasma samples from a cohort of clinically distinct patients with COVID-19 during acute infection. Plasma viral load was associated with systemic inflammatory cytokines that were elevated in severe COVID-19, and also with spike-specific neutralizing antibodies. By contrast, nasopharyngeal viral load correlated with SARS-CoV-2 humoral responses but inversely with interferon responses, the latter associating with protective microbial communities. Potential pathogenic microorganisms, often implicated in secondary respiratory infections, were associated with mucosal inflammation and elevated in severe COVID-19. Our results demonstrate distinct tissue compartmentalization of SARS-CoV-2 immune responses and highlight a role for the nasopharyngeal microbiome in regulating local and systemic immunity that determines COVID-19 clinical outcomes.
(© 2021. The Author(s).)
Databáze: MEDLINE
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