Low risk of SARS-CoV-2 transmission via fomite, even in cold-chain.

Autor:	Sobolik JS; Rollins School of Public Health, Emory University, Atlanta, GA, USA, 30322., Sajewski ET; Rollins School of Public Health, Emory University, Atlanta, GA, USA, 30322., Jaykus LA; Food, Bioprocessing and Nutrition Sciences, North Carolina State University, Raleigh, NC, USA, 27695., Cooper DK; Rollins School of Public Health, Emory University, Atlanta, GA, USA, 30322., Lopman BA; Rollins School of Public Health, Emory University, Atlanta, GA, USA, 30322., Kraay AN; Rollins School of Public Health, Emory University, Atlanta, GA, USA, 30322., Ryan PB; Rollins School of Public Health, Emory University, Atlanta, GA, USA, 30322., Guest JL; Rollins School of Public Health, Emory University, Atlanta, GA, USA, 30322., Webb-Girard A; Rollins School of Public Health, Emory University, Atlanta, GA, USA, 30322., Leon JS; Rollins School of Public Health, Emory University, Atlanta, GA, USA, 30322.
Jazyk:	angličtina
Zdroj:	MedRxiv : the preprint server for health sciences [medRxiv] 2021 Aug 26. Date of Electronic Publication: 2021 Aug 26.
DOI:	10.1101/2021.08.23.21262477
Abstrakt:	Background: Countries continue to debate the need for decontamination of cold-chain food packaging to reduce possible SARS-CoV-2 fomite transmission among workers. While laboratory-based studies demonstrate persistence of SARS-CoV-2 on surfaces, the likelihood of fomite-mediated transmission under real-life conditions is uncertain. Methods: Using a quantitative risk assessment model, we simulated in a frozen food packaging facility 1) SARS-CoV-2 fomite-mediated infection risks following worker exposure to contaminated plastic packaging; and 2) reductions in these risks attributed to masking, handwashing, and vaccination. Findings: In a representative facility with no specific interventions, SARS-CoV-2 infection risk to a susceptible worker from contact with contaminated packaging was 2·8 × 10 -3 per 1h-period (95%CI: 6·9 × 10 -6 , 2·4 × 10 -2 ). Implementation of standard infection control measures, handwashing and masks (9·4 × 10 -6 risk per 1h-period, 95%CI: 2·3 × 10 -8 , 8·1 × 10 -5 ), substantially reduced risk (99·7%). Vaccination of the susceptible worker (two doses Pfizer/Moderna, vaccine effectiveness: 86-99%) combined with handwashing and masking reduced risk to less than 1·0 × 10 -6 . Simulating increased infectiousness/transmissibility of new variants (2-, 10-fold viral shedding) among a fully vaccinated workforce, handwashing and masks continued to mitigate risk (2·0 × 10 -6 -1·1 × 10 -5 risk per 1h-period). Decontamination of packaging in addition to these interventions reduced infection risks to below the 1·0 × 10 -6 risk threshold. Interpretation: Fomite-mediated SARS-CoV-2 infection risks were very low under cold-chain conditions. Handwashing and masking provide significant protection to workers, especially when paired with vaccination. Funding: U.S. Department of Agriculture.
Databáze:	MEDLINE
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