Intestinal Colonization with Tropheryma whipplei -Clinical and Immunological Implications for HIV Positive Adults in Ghana.

Autor:	Eberhardt KA; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, 20359 Hamburg, Germany.; Institute for Transfusion Medicine, University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany., Sarfo FS; Department of Medicine, Kwame Nkrumah University of Science and Technology, 00233 Kumasi, Ghana.; Department of Medicine, Komfo Anokye Teaching Hospital, 00233 Kumasi, Ghana., Klupp EM; Institute of Medical Microbiology, Virology and Hygiene, University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany., Dompreh A; Department of Clinical Microbiology, Komfo Anokye Teaching Hospital, 00233 Kumasi, Ghana., Di Cristanziano V; Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50935 Cologne, Germany., Osei Kuffour E; Laboratory of Retrovirology, The Rockefeller University, New York, NY 10065, USA., Boateng R; Department of Clinical Microbiology, Komfo Anokye Teaching Hospital, 00233 Kumasi, Ghana., Norman B; Department of Medicine, Kwame Nkrumah University of Science and Technology, 00233 Kumasi, Ghana.; Department of Medicine, Komfo Anokye Teaching Hospital, 00233 Kumasi, Ghana., Phillips RO; Department of Medicine, Kwame Nkrumah University of Science and Technology, 00233 Kumasi, Ghana.; Department of Medicine, Komfo Anokye Teaching Hospital, 00233 Kumasi, Ghana.; Kumasi Center for Collaborative Research in Tropical Medicine, 00233 Kumasi, Ghana., Aepfelbacher M; Institute of Medical Microbiology, Virology and Hygiene, University Medical Centre Hamburg-Eppendorf, 20251 Hamburg, Germany., Feldt T; Clinic of Gastroenterology, Hepatology and Infectious Diseases, University Hospital Düsseldorf, 40225 Düsseldorf, Germany.
Jazyk:	angličtina
Zdroj:	Microorganisms [Microorganisms] 2021 Aug 22; Vol. 9 (8). Date of Electronic Publication: 2021 Aug 22.
DOI:	10.3390/microorganisms9081781
Abstrakt:	Background: Recent studies demonstrated higher prevalence rates of Tropheryma whipplei ( T. whipplei ) in HIV positive than in HIV negative subjects. However, associations with the immune status in HIV positive participants were conflicting. Methods: For this cross-sectional study, stool samples of 906 HIV positive and 98 HIV negative individuals in Ghana were tested for T. whipplei . Additionally, sociodemographic parameters, clinical symptoms, medical drug intake, and laboratory parameters were assessed. Results: The prevalence of T. whipplei was 5.85% in HIV positive and 2.04% in HIV negative participants. Within the group of HIV positive participants, the prevalence reached 7.18% in patients without co-trimoxazole prophylaxis, 10.26% in subjects with ART intake, and 12.31% in obese participants. Frequencies of clinical symptoms were not found to be higher in HIV positive T. whipplei carriers compared to T. whipplei negative participants. Markers of immune activation were lower in patients colonized with T. whipplei . Multivariate regression models demonstrated an independent relationship of a high CD4+ T cell count, a low HIV-1 viral load, and an obese body weight with the presence of T. whipplei . Conclusions: Among HIV positive individuals, T. whipplei colonization was associated with a better immune status but not with clinical consequences. Our data suggest that the withdrawal of co-trimoxazole chemoprophylaxis among people living with HIV on stable cART regimen may inadvertently increase the propensity towards colonization with T. whipplei .
Databáze:	MEDLINE
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