Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study.

Autor: Josev EK; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne 3052, Australia.; Department of Paediatrics, University of Melbourne, Melbourne 3052, Australia., Cole RC; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne 3052, Australia., Scheinberg A; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne 3052, Australia.; Department of Paediatrics, University of Melbourne, Melbourne 3052, Australia.; Department of Paediatrics, Monash University, Melbourne 3800, Australia.; Victorian Paediatric Rehabilitation Service, Royal Children's Hospital, Melbourne 3052, Australia., Rowe K; Department of General Medicine, Royal Children's Hospital, Melbourne 3052, Australia., Lubitz L; Department of General Medicine, Royal Children's Hospital, Melbourne 3052, Australia., Knight SJ; Neurodisability and Rehabilitation, Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne 3052, Australia.; Department of Paediatrics, University of Melbourne, Melbourne 3052, Australia.; Victorian Paediatric Rehabilitation Service, Royal Children's Hospital, Melbourne 3052, Australia.
Jazyk: angličtina
Zdroj: Journal of clinical medicine [J Clin Med] 2021 Aug 16; Vol. 10 (16). Date of Electronic Publication: 2021 Aug 16.
DOI: 10.3390/jcm10163603
Abstrakt: Background: The purpose of this study was to follow-up an Australian cohort of adolescents newly-diagnosed with ME/CFS at a tertiary paediatric ME/CFS clinic and healthy controls over a mean period of two years (range 1-5 years) from diagnosis. Objectives were to (a) examine changes over time in health and psychological wellbeing, (b) track ME/CFS symptomatology and fulfillment of paediatric ME/CFS diagnostic criteria over time, and (c) determine baseline predictors of ME/CFS criteria fulfilment at follow-up.
Methods: 34 participants aged 13-18 years (25 ME/CFS, 23 controls) completed standardised questionnaires at diagnosis (baseline) and follow-up assessing fatigue, sleep quality and hygiene, pain, anxiety, depression, and health-related quality of life. ME/CFS symptomatology and diagnostic criteria fulfilment was also recorded.
Results: ME/CFS patients showed significant improvement in most health and psychological wellbeing domains over time, compared with controls who remained relatively stable. However, fatigue, pain, and health-related quality of life remained significantly poorer amongst ME/CFS patients compared with controls at follow-up. Sixty-five percent of ME/CFS patients at baseline continued to fulfil ME/CFS diagnostic criteria at follow-up, with pain the most frequently experienced symptom. Eighty-two percent of patients at follow-up self-reported that they still had ME/CFS, with 79% of these patients fulfilling criteria. No significant baseline predictors of ME/CFS criteria fulfilment at follow-up were observed, although pain experienced at baseline was significantly associated with criteria fulfilment at follow-up ( R = 0.6, p = 0.02).
Conclusions: The majority of Australian adolescents with ME/CFS continue to fulfil diagnostic criteria at follow-up, with fatigue, pain, and health-related quality of life representing domains particularly relevant to perpetuation of ME/CFS symptoms in the early years following diagnosis. This has direct clinical impact for treating clinicians in providing a more realistic prognosis and highlighting the need for intervention with young people with ME/CFS at the initial diagnosis and start of treatment.
Databáze: MEDLINE
Externí odkaz: