Simultaneous Temperature Measurements and Aerosol Collection During Vaping for the Analysis of Δ 9 -Tetrahydrocannabinol and Vitamin E Acetate Mixtures in Ceramic Coil Style Cartridges.

Autor:	Lynch J; Forensic Chemistry Center, Office of Regulatory Science, Office of Regulatory Affairs, U.S. Food and Drug Administration, Cincinnati, OH, United States., Lorenz L; Forensic Chemistry Center, Office of Regulatory Science, Office of Regulatory Affairs, U.S. Food and Drug Administration, Cincinnati, OH, United States., Brueggemeyer JL; Forensic Chemistry Center, Office of Regulatory Science, Office of Regulatory Affairs, U.S. Food and Drug Administration, Cincinnati, OH, United States., Lanzarotta A; Forensic Chemistry Center, Office of Regulatory Science, Office of Regulatory Affairs, U.S. Food and Drug Administration, Cincinnati, OH, United States., Falconer TM; Forensic Chemistry Center, Office of Regulatory Science, Office of Regulatory Affairs, U.S. Food and Drug Administration, Cincinnati, OH, United States., Wilson RA; Forensic Chemistry Center, Office of Regulatory Science, Office of Regulatory Affairs, U.S. Food and Drug Administration, Cincinnati, OH, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in chemistry [Front Chem] 2021 Aug 09; Vol. 9, pp. 734793. Date of Electronic Publication: 2021 Aug 09 (Print Publication: 2021).
DOI:	10.3389/fchem.2021.734793
Abstrakt:	Incidence of e-cigarette, or vaping, product use-associated lung injury (EVALI) has been linked to the vaping of tetrahydrocannabinol (THC) products to which vitamin E acetate (VEA) has been added. In this work we vaped THC/VEA mixtures at elevated power levels using a variety of ceramic coil vaping cartridges and a commercially available vaping device, while simultaneously measuring temperature and collecting the vaporized condensate. The collected vapor condensate was analyzed for evidence of VEA decomposition by GC/MS, GC/FT-IR/MS, and LC-APCI-HRMS/MS. Mean temperature maxima for all examined cartridges at the selected power exceeded 430°C, with a range of 375-569°C, well beyond that required for thermal decomposition of VEA. The percent recovery of VEA and Δ 9 -THC from the vaporized mixture in six cartridges ranged from 71.5 to 101% and from 56.4 to 88.0%, respectively. Analysis of the condensed vaporized material identified VEA decomposition products duroquinone (DQ), 1-pristene, and durohydroquinone monoacetate (DHQMA); a compound consistent with 4-acetoxy-2,3,5-trimethyl-6-methylene-2,4-cyclohexadienone (ATMMC) was also detected. The concentration of DQ produced from vaporization of the THC/VEA mixture in one cartridge was found to be 4.16 ± 0.07 μg per mg of vapor condensate. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Lynch, Lorenz, Brueggemeyer, Lanzarotta, Falconer and Wilson.)
Databáze:	MEDLINE
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